The comparison effects of intra-articular injection of Platelet Rich Plasma (PRP), Plasma Rich in Growth Factor (PRGF), Hyaluronic Acid (HA), and ozone in knee osteoarthritis; a one year randomized clinical trial

This 2021 randomized clinical trial evaluated the short- and long-term efficacy of intra-articular injections of PRP, PRGF, HA, and ozone in 200 patients with mild to moderate knee osteoarthritis. Patients were randomized into four groups: PRP (2 doses, 3-week interval), PRGF (2 doses, 3-week interval), HA (3 weekly doses), and