Well Referenced

Tag: randomized clinical trial

Bone Health After Exercise Alone, GLP-1 Receptor Agonist Treatment, or Combination Treatment: A Secondary Analysis of a Randomized Clinical Trial

This 2024 secondary analysis of a randomized clinical trial examined the effects of exercise, GLP-1 receptor agonist (liraglutide) treatment, and their combination on bone health in adults with obesity. After an initial 8-week low-calorie diet, 195 participants were randomized into four groups: exercise alone, liraglutide alone, combination of both, or

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June 26, 2025 No Comments

Expression of Concern for “Extracorporeal Shock Wave Therapy Versus Phonophoresis Therapy for Neck Myofascial Pain Syndrome: A Randomized Clinical Trial”

This 2024 notice addresses concerns regarding a 2021 randomized clinical trial comparing extracorporeal shock wave therapy (ESWT) and phonophoresis therapy for neck myofascial pain syndrome (MPS). The original study involved 40 patients divided into two groups: one receiving three weekly sessions of ESWT, and the other undergoing phonophoresis therapy with

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June 26, 2025 No Comments

Intra-articular ozone or hyaluronic acid injection: Which one is superior in patients with knee osteoarthritis? A 6-month randomized clinical trial

This 2018 randomized clinical trial evaluated the efficacy of intra-articular ozone injections versus hyaluronic acid (HA) in 174 patients with knee osteoarthritis. Participants received three weekly injections of either 10 mL ozone (30 μg/mL) or HA (Hyalgan®). Outcomes assessed at baseline and 6 months included pain (VAS) and function (WOMAC).

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June 26, 2025 No Comments

The comparison effects of intra-articular injection of Platelet Rich Plasma (PRP), Plasma Rich in Growth Factor (PRGF), Hyaluronic Acid (HA), and ozone in knee osteoarthritis; a one year randomized clinical trial

This 2021 randomized clinical trial evaluated the short- and long-term efficacy of intra-articular injections of PRP, PRGF, HA, and ozone in 200 patients with mild to moderate knee osteoarthritis. Patients were randomized into four groups: PRP (2 doses, 3-week interval), PRGF (2 doses, 3-week interval), HA (3 weekly doses), and

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June 26, 2025 No Comments

Comparison of weight loss induced by daily caloric restriction versus intermittent fasting (DRIFT) in individuals with obesity: study protocol for a 52-week randomized clinical trial

The DRIFT study is a 52-week randomized clinical trial designed to compare the effectiveness of daily caloric restriction (DCR) and intermittent fasting (IMF) in promoting weight loss among individuals with obesity. Participants are randomized into two groups: one following DCR and the other following IMF, with both groups receiving equivalent

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June 26, 2025 No Comments

Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial

The STEP 8 trial was a 68-week, randomized, double-blind, double-dummy, phase 3 clinical study comparing once-weekly subcutaneous semaglutide 2.4 mg to once-daily subcutaneous liraglutide 3.0 mg in 338 adults with overweight or obesity without diabetes. Participants received lifestyle interventions alongside medication. Semaglutide led to a greater mean weight loss (−15.8%)

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June 26, 2025 No Comments

Effects of Cocoa Extract and a Multivitamin on Cognitive Function: A Randomized Clinical Trial

This 2023 randomized, double-blind, placebo-controlled trial (COSMOS-Mind) evaluated the effects of daily cocoa extract (500 mg flavanols) and a multivitamin-mineral (MVM) supplement on cognitive function in 2,262 older adults over three years. Cocoa extract supplementation showed no significant impact on global cognition, memory, or executive function. In contrast, daily MVM

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June 26, 2025 No Comments