This 2019 review investigates the neuroprotective properties of doxycycline in treating neurodegenerative diseases (NDs) such as Alzheimer's, Parkinson's, Huntington's, and prion diseases. Doxycycline acts via multiple pathways: it inhibits the aggregation of pathogenic proteins like amyloid-β and α-synuclein, suppresses neuroinflammation by attenuating microglial activation, and exhibits both antioxidant and anti-apoptotic
