The methylenetetrahydrofolate reductase 677C–>T polymorphism as a modulator of a B vitamin network with major effects on homocysteine metabolism

This study examines the effect of the MTHFR 677C-->T polymorphism on homocysteine metabolism and how it interacts with B vitamin supplementation in a large cohort of adults. The study found that individuals with the TT genotype had significantly higher plasma homocysteine levels compared to those with the CC or CT