This 2015 review by Stewart J. Tepper evaluates the evidence supporting nutraceutical, biobehavioral, and physical treatments for migraine and other headache disorders. For migraine prevention in adults, Level B evidence supports the use of feverfew, magnesium, and riboflavin (vitamin B2). Coenzyme Q10 (CoQ10) has Level C evidence, while melatonin has
This article provides a review of the use of nutraceuticals, including magnesium, riboflavin, coenzyme Q10, feverfew, and butterbur, for migraine prophylaxis. It highlights the growing body of evidence supporting the efficacy of these non-pharmacological treatments in reducing the frequency and severity of migraines, especially for patients dissatisfied with conventional medications.
This study examines the effect of the MTHFR 677C–>T polymorphism on homocysteine metabolism and how it interacts with B vitamin supplementation in a large cohort of adults. The study found that individuals with the TT genotype had significantly higher plasma homocysteine levels compared to those with the CC or CT
This observational study assessed the functional status of B vitamins—B6 (pyridoxine), B2 (riboflavin), and B1 (thiamine)—in patients with chronic fatigue syndrome (CFS) compared to healthy controls. Using red blood cell enzyme assays, the study found significantly reduced enzyme activity levels in CFS patients (p
This cross-sectional study analyzed data from 6,222 adults from NHANES (2007–2012) to investigate the relationship between the oxidative balance score (OBS)—a composite index reflecting dietary and lifestyle factors affecting oxidative stress—and thyroid function, focusing on free thyroxine (FT4) and total thyroxine (TT4). Using weighted multivariable linear regression, the study found
