Well Referenced

Tag: B vitamins

Natural products, micronutrients, and nutraceuticals for the treatment of depression: A short review

This 2017 review article explores the potential of natural compounds, micronutrients, and nutraceuticals in managing depression. It highlights the limitations of conventional antidepressants, such as delayed onset and adverse effects, and discusses alternative treatments. The review examines various natural substances, including green tea catechins, anthocyanins, cocoa extracts, resveratrol, omega-3 fatty

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June 26, 2025 No Comments

Intravenous Nutrient Therapy: the “Myers’ Cocktail”

This 2002 review by Dr. Alan R. Gaby discusses the clinical application of the “Myers’ cocktail,” an intravenous vitamin and mineral formula originally developed by Dr. John Myers. The modified cocktail typically includes magnesium, calcium, B vitamins, and vitamin C. Over an 11-year period, approximately 15,000 injections were administered to

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June 26, 2025 No Comments

Effects of Four-Week Supplementation with a Multi-Vitamin/Mineral Preparation on Mood and Blood Biomarkers in Young Adults: A Randomised, Double-Blind, Placebo-Controlled Trial

This randomized, double-blind, placebo-controlled trial assessed the impact of a four-week multivitamin and mineral (MVM) supplementation on mood and blood biomarkers in 58 healthy adults aged 18–40 years. Participants received either MVM or placebo daily. The MVM group exhibited significant reductions in depression-dejection scores on the Profile of Mood States

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June 26, 2025 No Comments

High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial

This randomized, double-blind, placebo-controlled trial assessed the efficacy of high-dose B vitamin supplementation (folic acid 5 mg, vitamin B6 25 mg, and vitamin B12 1 mg daily) in slowing cognitive decline among 409 individuals with mild to moderate Alzheimer’s disease over 18 months. Despite significant reductions in plasma homocysteine levels

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June 26, 2025 No Comments

The methylenetetrahydrofolate reductase 677C–>T polymorphism as a modulator of a B vitamin network with major effects on homocysteine metabolism

This study examines the effect of the MTHFR 677C–>T polymorphism on homocysteine metabolism and how it interacts with B vitamin supplementation in a large cohort of adults. The study found that individuals with the TT genotype had significantly higher plasma homocysteine levels compared to those with the CC or CT

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June 26, 2025 No Comments

Mitochondrial Dysfunction and Neurodegenerative Disorders: Role of Nutritional Supplementation

This systematic review examines the role of mitochondrial dysfunction in various neurodegenerative diseases—such as Parkinson’s disease, Alzheimer’s disease, ALS, multiple system atrophy, and progressive supranuclear palsy—and explores the potential benefits of nutritional supplementation with CoQ10, B-vitamins/NADH, L-carnitine, vitamin D, and alpha-lipoic acid. These nutrients are proposed to support mitochondrial ATP

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June 26, 2025 No Comments

The Role of Nutrients in Protecting Mitochondrial Function and Neurotransmitter Signaling: Implications for the Treatment of Depression, PTSD, and Suicidal Behaviors

This systematic review explores how specific nutrients—such as B vitamins (B6, B9, B12), omega-3 fatty acids, vitamin D, vitamin C, magnesium, zinc, and antioxidants—support mitochondrial function and neurotransmitter signaling, both of which are disrupted in mood disorders like depression, PTSD, and suicidal behavior. The review highlights that correcting nutritional deficiencies

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June 26, 2025 No Comments

B Vitamins and the Brain: Mechanisms, Dose and Efficacy–A Review

The review article titled “B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review” by David O. Kennedy, published in Nutrients in 2016 (PMID: 26828517), examines the essential roles of the eight B-vitamins in brain function, highlighting their involvement in energy production, DNA/RNA synthesis and repair, methylation processes, and the

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June 26, 2025 No Comments