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Tag: homocysteine metabolism

Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: metabolic significance, risks and impact on folate requirement

This article explores the impact of methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms on plasma homocysteine levels and the body’s response to folate supplementation. The study found that individuals with the T/T genotype had higher homocysteine levels and lower folate concentrations compared to those with the C/C or C/T genotypes, with folate

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June 26, 2025 No Comments

The Implication of a Polymorphism in the Methylenetetrahydrofolate Reductase Gene in Homocysteine Metabolism and Related Civilisation Diseases

This review article examines the impact of MTHFR (methylenetetrahydrofolate reductase) polymorphisms, specifically the C677T variant, on homocysteine metabolism and its association with various health risks, including cardiovascular disease, cancer, and neural tube defects. The T/T genotype is linked to higher homocysteine levels, which increases the risk for these conditions, particularly

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June 26, 2025 No Comments

The methylenetetrahydrofolate reductase 677C–>T polymorphism as a modulator of a B vitamin network with major effects on homocysteine metabolism

This study examines the effect of the MTHFR 677C–>T polymorphism on homocysteine metabolism and how it interacts with B vitamin supplementation in a large cohort of adults. The study found that individuals with the TT genotype had significantly higher plasma homocysteine levels compared to those with the CC or CT

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June 26, 2025 No Comments

Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium

This symposium summary discusses the roles of S-adenosylmethionine (SAMe), folate, and betaine in treating alcoholic liver disease (ALD), focusing on their biochemical functions and therapeutic potential. These compounds act as methyl donors essential for hepatic transmethylation reactions, impacting homocysteine metabolism and influencing gene expression related to liver health. Deficiencies in

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June 26, 2025 No Comments

B Vitamins and the Brain: Mechanisms, Dose and Efficacy–A Review

The review article titled “B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review” by David O. Kennedy, published in Nutrients in 2016 (PMID: 26828517), examines the essential roles of the eight B-vitamins in brain function, highlighting their involvement in energy production, DNA/RNA synthesis and repair, methylation processes, and the

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June 26, 2025 No Comments