Well Referenced

Tag: systematic review

Correction: Low Carbohydrate versus Isoenergetic Balanced Diets for Reducing Weight and Cardiovascular Risk: A Systematic Review and Meta-Analysis

This 2018 correction notice addresses errors in the original 2014 systematic review and meta-analysis comparing low-carbohydrate diets to isoenergetic balanced diets for weight loss and cardiovascular risk reduction. The original study concluded that low-carbohydrate diets were more effective for short-term weight loss but did not provide significant cardiovascular benefits over

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June 26, 2025 No Comments

Protocol for Treatment of Achilles Tendon Ruptures: A Systematic Review with Network Meta-Analysis

This 2018 protocol outlines a systematic review and network meta-analysis (NMA) to evaluate the comparative effectiveness of various treatment strategies for acute Achilles tendon ruptures. The study aims to synthesize evidence from randomized controlled trials (RCTs) with a minimum 6-month follow-up, focusing on both operative (open and minimally invasive surgery)

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June 26, 2025 No Comments

Effectiveness and Safety of Ketamine for Unipolar Depression: a Systematic Review

This systematic review evaluated 35 randomized controlled trials assessing the efficacy and safety of ketamine in treating Major Depressive Disorder (MDD). Intravenous (IV) ketamine demonstrated significant antidepressant effects in 70% of the studies, while oral and intranasal routes showed limited efficacy. Common adverse effects included nausea, vomiting, dizziness, diplopia, drowsiness,

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June 26, 2025 No Comments

Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis

This 2012 systematic review and meta-analysis assessed the efficacy and safety of berberine in managing type 2 diabetes mellitus (T2DM). Analyzing 14 randomized controlled trials involving 1,068 participants, the study found that berberine significantly improved glycemic control and lipid profiles compared to lifestyle modifications or placebo. When compared to standard

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June 26, 2025 No Comments

Genetic Variants of Glucose-6-Phosphate Dehydrogenase and Their Associated Enzyme Activity: A Systematic Review and Meta-Analysis

This 2022 systematic review and meta-analysis evaluated the relationship between specific G6PD gene variants and their corresponding enzyme activity levels. The study compiled individual patient data from 17 studies across 10 countries, encompassing 4,320 individuals, including 1,738 with one of 24 confirmed G6PD mutations. The analysis revealed significant variability in

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June 26, 2025 No Comments

The Efficacy and Use of Finasteride in Women: A Systematic Review

This 2019 systematic review evaluated the use of finasteride in women for treating hair disorders such as female pattern hair loss (FPHL), frontal fibrosing alopecia (FFA), and lichen planopilaris. It included various study designs—mainly observational—with treatment doses ranging from 0.5 mg to 5 mg daily and durations spanning 6 to

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June 26, 2025 No Comments

Efficacy of Non-Surgical Treatments for Androgenetic Alopecia: A Systematic Review and Network Meta-Analysis

This 2018 systematic review and network meta-analysis evaluated the comparative effectiveness of six non-surgical treatments for androgenetic alopecia (AGA): dutasteride 0.5 mg, finasteride 1 mg, low-level laser therapy (LLLT), minoxidil 2%, minoxidil 5%, and platelet-rich plasma (PRP). The review included 78 studies, with 22 qualifying for quantitative synthesis. LLLT demonstrated

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June 26, 2025 No Comments

Chelation Therapy in Patients With Cardiovascular Disease: A Systematic Review

This systematic review evaluated the efficacy of ethylenediaminetetraacetic acid (EDTA) chelation therapy in patients with pre-existing cardiovascular disease (CVD). Analyzing 24 studies—including 4 randomized clinical trials, 15 prospective before/after studies, and 5 retrospective case series—the review found that 17 studies reported improved outcomes following EDTA treatment. Notably, the most significant

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June 26, 2025 No Comments

Environmental Toxic Metal Contaminants and Risk of Cardiovascular Disease: Systematic Review and Meta-Analysis

This comprehensive systematic review and meta-analysis investigated the relationship between exposure to environmental toxic metals—arsenic, lead, cadmium, mercury, and copper—and the incidence of cardiovascular disease (CVD), including coronary heart disease (CHD) and stroke. Drawing from 37 studies with over 348,000 participants, the analysis revealed that higher levels of arsenic, lead,

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June 26, 2025 No Comments