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Tag: reactive oxygen species

Induction of Mitochondrial Dysfunction and Oxidative Damage by Antibiotic Drug Doxycycline Enhances the Responsiveness of Glioblastoma to Chemotherapy

This 2017 study investigates the effects of doxycycline, an FDA-approved antibiotic, on glioblastoma cells. Doxycycline induces mitochondrial dysfunction, leading to decreased mitochondrial membrane potential, reduced ATP production, and increased reactive oxygen species (ROS) levels. These changes result in oxidative damage to DNA, proteins, and lipids, causing cell cycle arrest and

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June 26, 2025 No Comments

Iron Overload and Breast Cancer: Iron Chelation as a Potential Therapeutic Approach

This 2022 review explores the role of iron overload in breast cancer development and progression. Excess iron, particularly non-transferrin-bound iron (NTBI), can catalyze free radical reactions, leading to oxidative stress and DNA damage. Estrogen can exacerbate this by disrupting iron metabolism, further increasing reactive oxygen species (ROS) production. The study

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June 26, 2025 No Comments

Long-chain fatty acid analogues suppress breast tumorigenesis and progression

This 2014 study investigates the antitumor effects of MEDICA analogues, synthetic long-chain fatty acid derivatives, in breast cancer models. In the MMTV-PyMT mouse model, MEDICA treatment significantly reduced tumor growth and lung metastasis, promoting a more differentiated tumor phenotype. Mechanistically, MEDICA compounds elevated reactive oxygen species (ROS) levels, leading to

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June 26, 2025 No Comments

Combination Therapy with Vitamin C Could Eradicate Cancer Stem Cells

This review evaluates the role of high-dose vitamin C (ascorbic acid) as a complementary treatment in targeting cancer stem cells (CSCs), which are key drivers of tumor initiation, resistance, and relapse. The authors describe mechanisms by which vitamin C exerts selective cytotoxic effects on CSCs, including induction of oxidative stress

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June 26, 2025 No Comments

Contribution of reactive oxygen species to ovarian cancer cell growth arrest and killing by the anti-malarial drug artesunate

This preclinical study explores the anti-cancer effects of artesunate (ART), a derivative of artemisinin traditionally used for malaria, in ovarian cancer models. ART was shown to suppress growth of multiple ovarian cancer cell lines and patient-derived primary cells, and to inhibit tumor progression in xenograft mouse models. The treatment significantly

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June 26, 2025 No Comments

Biology of ageing and role of dietary antioxidants

This 2014 review examines the role of dietary antioxidants in the aging process. It highlights that while oxygen is essential for aerobic organisms, it also leads to the continuous generation of reactive oxygen species (ROS), which are implicated in aging. The body’s antioxidant defense system, comprising enzymes like superoxide dismutase

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June 26, 2025 No Comments

Oxidative Stress and Male Infertility: The Protective Role of Antioxidants

This review examines the impact of oxidative stress (OS) on male infertility and the potential protective effects of antioxidants. OS, resulting from an imbalance between reactive oxygen species (ROS) and antioxidant defenses, can impair sperm function by causing lipid peroxidation, DNA damage, and apoptosis. The article discusses various antioxidants, including

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June 26, 2025 No Comments

Ozonated Oils and Cutaneous Wound Healing

This 2019 systematic review titled “Ozonated Oils and Cutaneous Wound Healing” (Current Pharmaceutical Design, DOI: [10.2174/1381612825666190702100504*) examined numerous experimental and clinical studies on the use of ozonated oils in wound healing. The findings highlight ozonated oils’ potent antimicrobial properties (bactericidal, antiviral, and antifungal), as well as their ability to modulate

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June 26, 2025 No Comments

Ozonated Oils as Antimicrobial Systems in Topical Applications. Their Characterization, Current Applications, and Advances in Improved Delivery Techniques

This 2020 systematic review titled “Ozonated Oils as Antimicrobial Systems in Topical Applications. Their Characterization, Current Applications, and Advances in Improved Delivery Techniques” (Molecules, DOI: [10.3390/molecules25020334*) explores the chemical properties, antimicrobial mechanisms, and evolving applications of ozonated oils in medical, cosmetic, and textile fields. The review highlights that ozonated oils

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June 26, 2025 No Comments

Ozone and ozonated oils in skin diseases: a review

This 2010 systematic review titled “Ozone and ozonated oils in skin diseases: a review” (Mediators of Inflammation, DOI: [10.1155/2010/610418*) discusses the chemistry, therapeutic potential, and formulation considerations of ozonated oils for dermatological use. Highlighting the formation of ozonides and peroxides through the reaction of ozone with unsaturated triglycerides, the review

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June 26, 2025 No Comments