Contribution of reactive oxygen species to ovarian cancer cell growth arrest and killing by the anti-malarial drug artesunate

This preclinical study explores the anti-cancer effects of artesunate (ART), a derivative of artemisinin traditionally used for malaria, in ovarian cancer models. ART was shown to suppress growth of multiple ovarian cancer cell lines and patient-derived primary cells, and to inhibit tumor progression in xenograft mouse models. The treatment significantly