Well Referenced

Tag: memory enhancement

Therapeutic and preventive effects of methylene blue on Alzheimer’s disease pathology in a transgenic mouse model

The study titled “Therapeutic and preventive effects of methylene blue on Alzheimer’s disease pathology in a transgenic mouse model” investigated the impact of methylene blue (MB) on cognitive function and amyloid pathology in APP/PS1 transgenic mice. Both oral and intraperitoneal MB treatments were administered either before or after the onset

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June 26, 2025 No Comments

Beneficial network effects of methylene blue in an amnestic model

This study evaluated the neuroprotective effects of methylene blue (MB) in an animal model of mitochondrial dysfunction-induced hypometabolism in the posterior cingulate cortex (PCC), a condition linked to memory deficits similar to those seen in Alzheimer’s disease. Rats receiving sodium azide infusions exhibited significant visuospatial memory impairments and reduced cytochrome

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June 26, 2025 No Comments

Cellular and molecular actions of Methylene Blue in the nervous system

Methylene blue (MB) has demonstrated potential therapeutic benefits in neuroprotection, mood disorders, and neurodegenerative diseases such as Alzheimer’s. This review highlights MB’s mechanisms of action, including its inhibition of monoamine oxidase A (MAO-A), which increases serotonin and dopamine levels, and its modulation of the cyclic guanosine monophosphate (cGMP) pathway, which

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June 26, 2025 No Comments

Methylene blue facilitates the extinction of fear in an animal model of susceptibility to learned helplessness

This study examined the effects of methylene blue on the extinction of conditioned fear responses in rats predisposed to learned helplessness. The results demonstrated that methylene blue administration enhanced the extinction of fear, suggesting its potential role in influencing memory processes related to fear. This finding has implications for developing

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June 26, 2025 No Comments

Methylene blue improves brain oxidative metabolism and memory retention in rats

This study investigated the effects of methylene blue (MB) on brain oxidative metabolism and memory retention in rats. The results showed that MB administration significantly enhanced cytochrome c oxidase activity, which boosted brain oxidative metabolism. Rats treated with MB exhibited a marked improvement in spatial memory retention, with treated rats

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June 26, 2025 No Comments

Methylene blue improves streptozotocin-induced memory deficit by restoring mitochondrial function in rats

This study explored the effects of methylene blue (MB) on memory deficits and mitochondrial function in rats with streptozotocin (STZ)-induced cognitive impairment. The results showed that MB treatment significantly improved memory performance in the passive avoidance test and restored mitochondrial function, evidenced by increased ATP levels and reduced oxidative stress

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June 26, 2025 No Comments

Decrypting the potential role of α-lipoic acid in Alzheimer’s disease

The article titled “Decrypting the potential role of α-lipoic acid in Alzheimer’s disease” (Life Sciences, 2021, PMID: 34450170) reviews the neuroprotective effects of alpha-lipoic acid (α-LA) in Alzheimer’s disease (AD), which is characterized by amyloid-β plaques, tau protein accumulation, oxidative stress, and mitochondrial dysfunction. The review highlights α-LA’s antioxidant, antiapoptotic,

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June 26, 2025 No Comments