This 2007 review examines the metabolic impacts of high-protein diets, particularly in weight-stable individuals. Findings indicate that higher protein intake is associated with lower blood pressure and, in diabetic patients, reduced glycosylated hemoglobin levels. However, the long-term effects on atherosclerosis risk remain unclear due to limited and conflicting epidemiological data.
This 12-week double-blind, randomized controlled trial investigated the effects of a green tea extract (GTE) high in catechins on body fat and cardiovascular risk factors in Japanese adults with visceral obesity. Participants consumed either a beverage containing 583 mg of catechins or a control beverage with 96 mg of catechins
This randomized trial evaluated the effects of low-carbohydrate and low-fat diets on weight and metabolic outcomes over two years in overweight and obese adults. Participants were assigned to either a low-carbohydrate diet (starting at 20 g/day of carbohydrates, gradually increasing) or a low-fat diet (1200–1800 kcal/day with ≤30% of calories
This pilot study evaluated the effects of major autohemotherapy with ozone infusion on reducing growth/differentiation factor-15 (GDF-15) and LDL cholesterol in patients with type-2 diabetes mellitus (T2DM). The treatment, administered twice weekly for 10 sessions, resulted in a significant reduction in GDF-15 and LDL cholesterol levels in the T2DM group,
This randomized controlled trial investigated the effects of methylfolate, pyridoxal-5′-phosphate, and methylcobalamin supplementation on homocysteine and LDL cholesterol levels in patients with MTHFR, MS, and MTRR polymorphisms. The study found significant reductions in both homocysteine and LDL cholesterol, especially in those with MTHFR C677T polymorphisms, suggesting that targeted supplementation can
This systematic review and meta-analysis examined the effects of olive leaf extract (OLE) on cardiometabolic health in 325 adults with prehypertension or hypertension across five randomized controlled trials. Supplementation with 500 mg/day of OLE for at least 8 weeks significantly reduced systolic blood pressure by 5.78 mmHg and improved LDL
This observational study of 8,389 middle-aged Chinese adults revealed that elevated high-sensitivity C-reactive protein (hs-CRP) levels correlated strongly with age, blood pressure, glucose, BMI, and LDL cholesterol. About 63% of individuals with coexisting hypertension, diabetes, high cholesterol, and obesity had hs-CRP concentrations in the top quartile. These findings underscore hs-CRP’s
The study evaluated the efficacy of evacetrapib, a CETP inhibitor, in reducing major adverse cardiovascular events (MACE) despite its ability to significantly raise HDL cholesterol by 130% and lower LDL cholesterol by 37%. Conducted on over 12,000 high-risk cardiovascular patients, the trial was halted early due to a lack of
The randomized, double-blind clinical trial titled “Effects of short-term administration of dehydroepiandrosterone (DHEA) on body composition, cholesterol, and insulin sensitivity in normal men” (Journal of Clinical Endocrinology & Metabolism, 1985, PMID: 25879093) investigated the metabolic impact of high-dose DHEA (1,600 mg/day for 28 days) in five healthy male subjects. DHEA
This study examined the association between urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels, a biomarker of oxidative stress, and various health and occupational factors in 503 male workers. Findings revealed that higher urinary 8-OHdG levels were linked to high blood sugar and leanness in smokers, while exposure to organic solvents, hydrochloric acid, and
