Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensitivity in normal men

The randomized, double-blind clinical trial titled "Effects of short-term administration of dehydroepiandrosterone (DHEA) on body composition, cholesterol, and insulin sensitivity in normal men" (Journal of Clinical Endocrinology & Metabolism, 1985, PMID: 25879093) investigated the metabolic impact of high-dose DHEA (1,600 mg/day for 28 days) in five healthy male subjects. DHEA