This observational study of 8,389 middle-aged Chinese adults revealed that elevated high-sensitivity C-reactive protein (hs-CRP) levels correlated strongly with age, blood pressure, glucose, BMI, and LDL cholesterol. About 63% of individuals with coexisting hypertension, diabetes, high cholesterol, and obesity had hs-CRP concentrations in the top quartile. These findings underscore hs-CRP’s