Well Referenced

Tag: folate supplementation

The importance of folate, vitamins B6 and B12 for the lowering of homocysteine concentrations for patients with recurrent pregnancy loss and MTHFR mutations

This study investigated the effects of supplementation with methylfolate, vitamin B6, and vitamin B12 on plasma homocysteine levels and pregnancy outcomes in women with recurrent pregnancy loss (RPL) and MTHFR mutations. Sixteen women with RPL and confirmed MTHFR mutations were randomized to receive the supplements for a year, resulting in

Read More »
June 26, 2025 No Comments

Homocysteine and MTHFR Mutations

This review article discusses the role of MTHFR mutations, particularly the C677T and A1298C polymorphisms, in elevating homocysteine levels, which are associated with an increased risk of cardiovascular diseases such as stroke and heart attack. The review highlights that while MTHFR mutations alone do not directly cause cardiovascular disease, they

Read More »
June 26, 2025 No Comments

Isolated remethylation disorders: do our treatments benefit patients?

This review article discusses isolated remethylation disorders, such as deficiencies in MTHFR and other rare defects like methionine synthase, which impair methionine synthesis and lead to elevated homocysteine levels. These disorders manifest with neurological and hematological symptoms and can lead to severe neurological deterioration or death without early intervention. Treatment

Read More »
June 26, 2025 No Comments

MTHFR isoform carriers. 5-MTHF (5-methyl tetrahydrofolate) vs folic acid: a key to pregnancy outcome: a case series

This observational study explored the effects of 5-methyl tetrahydrofolate (5-MTHF) compared to synthetic folic acid in couples with MTHFR isoform mutations (C677T and A1298C), which are linked to fertility issues and recurrent fetal loss. It found that 5-MTHF supplementation might improve pregnancy outcomes by bypassing metabolic defects caused by the

Read More »
June 26, 2025 No Comments

Polymorphisms of key enzymes in homocysteine metabolism affect diet responsiveness of plasma homocysteine in healthy women

This study examined the effect of genetic polymorphisms in enzymes involved in homocysteine metabolism (MTHFR, CBS, and MS) on plasma homocysteine responses to dietary folate in healthy women. Participants (n=37) underwent a crossover dietary intervention with low and high folate diets. Results showed that high folate intake significantly increased serum

Read More »
June 26, 2025 No Comments

Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: metabolic significance, risks and impact on folate requirement

This article explores the impact of methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms on plasma homocysteine levels and the body’s response to folate supplementation. The study found that individuals with the T/T genotype had higher homocysteine levels and lower folate concentrations compared to those with the C/C or C/T genotypes, with folate

Read More »
June 26, 2025 No Comments

The Implication of a Polymorphism in the Methylenetetrahydrofolate Reductase Gene in Homocysteine Metabolism and Related Civilisation Diseases

This review article examines the impact of MTHFR (methylenetetrahydrofolate reductase) polymorphisms, specifically the C677T variant, on homocysteine metabolism and its association with various health risks, including cardiovascular disease, cancer, and neural tube defects. The T/T genotype is linked to higher homocysteine levels, which increases the risk for these conditions, particularly

Read More »
June 26, 2025 No Comments