Polymorphisms of key enzymes in homocysteine metabolism affect diet responsiveness of plasma homocysteine in healthy women

This study examined the effect of genetic polymorphisms in enzymes involved in homocysteine metabolism (MTHFR, CBS, and MS) on plasma homocysteine responses to dietary folate in healthy women. Participants (n=37) underwent a crossover dietary intervention with low and high folate diets. Results showed that high folate intake significantly increased serum