Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: metabolic significance, risks and impact on folate requirement

This article explores the impact of methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms on plasma homocysteine levels and the body's response to folate supplementation. The study found that individuals with the T/T genotype had higher homocysteine levels and lower folate concentrations compared to those with the C/C or C/T genotypes, with folate