The importance of folate, vitamins B6 and B12 for the lowering of homocysteine concentrations for patients with recurrent pregnancy loss and MTHFR mutations

This study investigated the effects of supplementation with methylfolate, vitamin B6, and vitamin B12 on plasma homocysteine levels and pregnancy outcomes in women with recurrent pregnancy loss (RPL) and MTHFR mutations. Sixteen women with RPL and confirmed MTHFR mutations were randomized to receive the supplements for a year, resulting in