This 2016 review explores the potential of various dietary phytochemicals in preventing and treating melanoma, emphasizing their low toxicity and public acceptance. Key compounds such as fisetin, epigallocatechin-3-gallate (EGCG), resveratrol, curcumin, proanthocyanidins, silymarin, apigenin, capsaicin, genistein, indole-3-carbinol, and luteolin are highlighted for their ability to modulate multiple signaling pathways involved