This 2017 review evaluates the role of phytochemicals in the chemoprevention of melanoma, discussing their mechanisms in modulating critical molecular pathways such as MAPK, PI3K/AKT, and NF-κB. Compounds like fisetin, EGCG, resveratrol, curcumin, and silymarin are shown to inhibit melanoma cell proliferation, induce apoptosis, and suppress metastasis in preclinical models.