This 2024 multicenter, prospective study by Hanson et al. evaluated the point accuracy of two leading continuous glucose monitoring (CGM) systems: Dexcom G7 and FreeStyle Libre 3. Involving 55 adults with type 1 or type 2 diabetes, the study compared sensor readings against laboratory reference values. The FreeStyle Libre 3
This 2019 in vitro study titled “Personalizing the Safe, Appropriate and Effective Concentration(s) of Ozone for a Non-Diabetic Individual and Four Type II Diabetic Patients in Autohemotherapy through Blood Hemoglobin Analysis” (Journal of Translational Medicine, DOI: [10.1186/s12967-019-1973-5*) investigated how different concentrations of ozone affect the structural and functional integrity of
This 2017 narrative review titled “Therapeutic Relevance of Ozone Therapy in Degenerative Diseases: Focus on Diabetes and Spinal Pain” (Journal of Cellular Physiology, DOI: [10.1002/jcp.26044]*) critically examined how controlled, low-dose ozone therapy activates key molecular pathways including HIF-1α, NFAT, Nrf2-ARE, and AP-1, leading to upregulation of antioxidant defenses, modulation of
This clinical trial examined the effects of long-term magnesium supplementation on the progression of diabetic neuropathy in magnesium-deficient patients with type 1 diabetes mellitus (T1DM). The study found that sustained magnesium intake favorably influenced the natural evolution of neuropathy, suggesting therapeutic potential for magnesium in managing nerve-related complications of diabetes.
This narrative review discusses the powerful antioxidant properties of dietary polyphenols, found in foods like fruits, vegetables, and beverages such as tea and wine. The review highlights how these compounds help mitigate oxidative stress, which is a contributor to chronic diseases such as neurodegenerative disorders, cardiovascular diseases, cancer, diabetes, and
This systematic review explores the diverse pharmacological effects of ginseng, focusing on its active compounds—ginsenosides and polysaccharides—and their impact on human health. Drawing from 20 years of clinical studies, primarily in developed countries, the review highlights ginseng’s adaptogenic properties, which help regulate physiological processes and promote homeostasis. It demonstrates beneficial
This meta-analysis demonstrated that subcutaneous semaglutide significantly reduced body weight by up to 14.9%, improved glycemic control with an average HbA1c reduction of 1.7%, and had a manageable safety profile dominated by gastrointestinal side effects. It involved over 1,961 participants, predominantly adults with obesity, and highlighted semaglutide’s potential to enhance
This study investigates the effects of methylene blue (MB) on mitochondrial function and oxidative stress in diabetic rat heart mitochondria. The results showed that MB administration enhanced mitochondrial respiration in both healthy and diabetic rat hearts, particularly when complex I and II substrates were used. However, MB increased hydrogen peroxide
This study investigates the effects of hyperbaric oxygen therapy (HBOT) on diabetic wounds, demonstrating that it significantly reduces oxidative stress and inflammation, while increasing growth factors that support healing. Conducted on 50 diabetic patients with foot ulcers, the therapy showed a 30% reduction in oxidative stress markers, a 25% decrease
This systematic review examines the effects of testosterone replacement therapy (TRT) in men with impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM). The review found that TRT improves body composition, insulin resistance, and glucose profiles, suggesting that it could be beneficial for hypogonadal men with metabolic disorders. However,
