The article “Effects of DHEA on metabolic and endocrine functions of adipose tissue” explores the role of dehydroepiandrosterone (DHEA), a steroid hormone precursor to androgens and estrogens, in regulating fat tissue metabolism. The study examines how DHEA influences lipid metabolism, insulin sensitivity, and adipokine secretion, which are critical in energy
A single-blind, placebo-controlled crossover study examined the effects of dehydroepiandrosterone (DHEA) administration on 24-hour plasma cortisol levels in healthy older adults. Participants received either a placebo or 200 mg of oral DHEA daily for 15 days. The study found that DHEA administration significantly reduced plasma cortisol concentrations, with a more
The study “Low serum levels of sex steroids are associated with disease characteristics in primary Sjögren’s syndrome; supplementation with dehydroepiandrosterone restores the concentrations” investigated the impact of dehydroepiandrosterone (DHEA) supplementation on sex hormone levels and disease symptoms in postmenopausal women with primary Sjögren’s syndrome (pSS). In this randomized, placebo-controlled, 9-month
The randomized controlled trial titled “Dehydroepiandrosterone supplementation enhances immune function in HIV-positive subjects with undetectable viral load” (Clinical Infectious Diseases, 2007, PMID: 17263636) investigated whether supplementation with dehydroepiandrosterone (DHEA) could influence HIV replication and immune function. The study found that DHEA did not significantly alter viral load or CD4+ T-cell
The meta-analysis titled “Dehydroepiandrosterone (DHEA) supplementation for depression: a systematic review and meta-analysis” (Psychoneuroendocrinology, 2018, PMID: 30124161) examined the efficacy of DHEA supplementation for reducing depressive symptoms across multiple randomized controlled trials. The findings indicated that DHEA supplementation demonstrated a moderate antidepressant effect and was generally well-tolerated, though mild side
The systematic review titled “Dehydroepiandrosterone (DHEA) supplementation for cognitive function in healthy elderly individuals” (Cochrane Database of Systematic Reviews, 2001, DOI: 10.1002/14651858.CD000304) analyzed data from three randomized controlled trials with a total of 145 healthy participants aged 55 and older. The review found no significant cognitive benefits from DHEA supplementation
The systematic review titled “Dehydroepiandrosterone (DHEA) Supplementation in Rheumatic Diseases” (Mediterranean Journal of Rheumatology, 2023, DOI: 10.31138/mjr.20230825.dd) evaluated the effectiveness of DHEA in patients with systemic lupus erythematosus (SLE), Sjögren’s syndrome (SS), rheumatoid arthritis (RA), and fibromyalgia (FM) across 21 studies. DHEA supplementation notably improved bone mineral density, reduced fatigue,
This pooled analysis of four randomized controlled trials examined the sex-specific effects of dehydroepiandrosterone (DHEA) therapy on bone mineral density (BMD) and body composition in older adults. The study found that DHEA supplementation led to a 1.0% increase in lumbar spine BMD in women over 12 months, while men experienced
This study evaluated the effects of dehydroepiandrosterone (DHEA) and hormone replacement therapy (HRT) in postmenopausal women, finding that DHEA alone significantly increased androgen levels and reduced cortisol, with a more substantial effect when combined with HRT. The combination therapy produced higher levels of testosterone and estradiol, improving overall hormonal balance.
This review examines the pharmacological treatment options for women’s sexual dysfunction, focusing on therapies targeting reduced sexual desire and arousal. Local estrogen therapy has been shown to improve genital vasocongestion and alleviate symptoms of vulvar and vaginal atrophy, while phosphodiesterase inhibitors may benefit women with autonomic neuropathies. Intravaginal DHEA, which
