Well Referenced

Tag: Cognitive Function

A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects

This 2018 pilot study assessed the safety and feasibility of daily 1 mg rapamycin administration over 8 weeks in 25 healthy older adults aged 70–95. The treatment was generally well-tolerated, with minor adverse events including facial rash, stomatitis, and gastrointestinal discomfort. Notably, there were statistically significant reductions in erythrocyte parameters

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June 26, 2025 No Comments

Pharmacological Effects of Ginseng: Multiple Constituents and Multiple Actions on Humans

This systematic review explores the diverse pharmacological effects of ginseng, focusing on its active compounds—ginsenosides and polysaccharides—and their impact on human health. Drawing from 20 years of clinical studies, primarily in developed countries, the review highlights ginseng’s adaptogenic properties, which help regulate physiological processes and promote homeostasis. It demonstrates beneficial

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June 26, 2025 No Comments

Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

This randomized, double-blind, placebo-controlled trial examined the effects of citicoline supplementation (500 mg/day for 12 weeks) on memory function in 100 healthy older adults (ages 50-85) with age-associated memory impairment (AAMI). The citicoline group showed significant improvements in episodic memory (p=0.0025) and overall memory performance (p=0.0052) compared to the placebo.

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June 26, 2025 No Comments

Effects of different fatty acids composition of phosphatidylcholine on brain function of dementia mice induced by scopolamine

This observational study examined the effects of phosphatidylcholine (PC) with different fatty acid compositions on cognitive function and oxidative stress in mice with scopolamine-induced cognitive decline. Mice supplemented with PC rich in EPA (sea cucumber PC) and DHA (squid PC) showed significant improvements in learning and memory performance, reduced acetylcholinesterase

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June 26, 2025 No Comments

Positive effects of soy lecithin-derived phosphatidylserine plus phosphatidic acid on memory, cognition, daily functioning, and mood in elderly patients with Alzheimer’s disease and dementia

This study examines the effects of soy lecithin-derived phosphatidylserine (PS) and phosphatidic acid (PA) supplementation on memory, cognition, daily functioning, and mood in elderly individuals, particularly those with Alzheimer’s disease (AD) and dementia. The results showed significant improvements in memory, mental health, and mood, with a 49% improvement in general

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June 26, 2025 No Comments

Feasibility of Vitamin C in the Treatment of Post Viral Fatigue with Focus on Long COVID, Based on a Systematic Review of IV Vitamin C on Fatigue

This systematic review examined the effectiveness and feasibility of high-dose intravenous (IV) vitamin C in treating fatigue, particularly in post-viral contexts such as long COVID. Across nine studies with 720 participants, three of four controlled trials and four of five observational studies showed a significant reduction in fatigue levels in

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June 26, 2025 No Comments

The Effects of Vitamin B in Depression

This systematic review examines the role of B-vitamin deficiencies—specifically B1, B3, B6, B9 (folate), and B12—in the development and severity of depression and cognitive decline. These vitamins are essential for neurotransmitter synthesis, methylation, homocysteine reduction, and neuronal membrane integrity. The review highlights that deficiencies in these vitamins are associated with

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June 26, 2025 No Comments

The influence of testosterone combined with a PDE5-inhibitor on cognitive, affective, and physiological sexual functioning in women suffering from sexual dysfunction

This randomized controlled trial examined the effects of combining testosterone and vardenafil (a PDE5 inhibitor) on cognitive, affective, and physiological sexual functions in 28 women with sexual dysfunction. The study found that in women with low initial attention to sexual cues, testosterone increased sensitivity to these cues, and the combination

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June 26, 2025 No Comments

Therapeutic and preventive effects of methylene blue on Alzheimer’s disease pathology in a transgenic mouse model

The study titled “Therapeutic and preventive effects of methylene blue on Alzheimer’s disease pathology in a transgenic mouse model” investigated the impact of methylene blue (MB) on cognitive function and amyloid pathology in APP/PS1 transgenic mice. Both oral and intraperitoneal MB treatments were administered either before or after the onset

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June 26, 2025 No Comments