Well Referenced

Tag: Cognitive Function

Lithium and dementia: a preliminary study

This 2006 observational study examined whether lithium use is associated with cognitive benefits in older adults. Researchers reviewed clinical records of 1,423 psychiatric outpatients aged 60 and above, comparing those with current or past lithium prescriptions to age- and gender-matched controls without lithium exposure. Although there was no significant difference

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June 26, 2025 No Comments

Effects of Cocoa Extract and a Multivitamin on Cognitive Function: A Randomized Clinical Trial

This 2023 randomized, double-blind, placebo-controlled trial (COSMOS-Mind) evaluated the effects of daily cocoa extract (500 mg flavanols) and a multivitamin-mineral (MVM) supplement on cognitive function in 2,262 older adults over three years. Cocoa extract supplementation showed no significant impact on global cognition, memory, or executive function. In contrast, daily MVM

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June 26, 2025 No Comments

Risk of Dementia and Parkinson’s Disease in Patients Treated with Androgen Deprivation Therapy Using Gonadotropin-Releasing Hormone Agonist for Prostate Cancer: A Nationwide Population-Based Cohort Study

This 2020 nationwide population-based cohort study investigated the association between androgen deprivation therapy (ADT) using gonadotropin-releasing hormone agonists (GnRHa) and the risk of developing dementia and Parkinson’s disease in prostate cancer patients. The study analyzed data from 3,201 GnRHa users and 4,123 nonusers, employing traditional and propensity score-matched Cox proportional

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June 26, 2025 No Comments

Hyperbaric Oxygen Treatment Improved Neurophysiologic Performance in Brain Tumor Patients After Neurosurgery and Radiotherapy: A Preliminary Report

This 2011 pilot study assessed the effects of hyperbaric oxygen therapy (HBOT) on cognitive function in 10 long-term brain tumor survivors experiencing severe cognitive deficits post-neurosurgery and radiotherapy. Participants underwent HBOT sessions, and neurophysiological assessments were conducted before treatment, and at 6 weeks and 4 months post-treatment. Results indicated a

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June 26, 2025 No Comments

Testosterone therapy improves well being and psychological health

This review evaluates the impact of testosterone therapy (TTh) on psychological health and overall well-being in men with symptomatic hypogonadism. Evidence indicates that TTh can lead to modest yet consistent improvements in mood, energy levels, libido, and cognitive function. These benefits are particularly relevant for men experiencing fatigue, depression, and

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June 26, 2025 No Comments

Androgen therapy in women: for whom and when

This 2013 review discusses the clinical use of androgen therapy in women, particularly for those experiencing hypoactive sexual desire disorder (HSDD). It highlights the role of androgens in sexual function, behavior, and cognition, noting that adrenal androgens may influence sexual symptoms and cognitive function in postmenopausal women. The article emphasizes

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June 26, 2025 No Comments

A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects

This 2018 pilot study assessed the safety and feasibility of daily 1 mg rapamycin administration over 8 weeks in 25 healthy older adults aged 70–95. The treatment was generally well-tolerated, with minor adverse events including facial rash, stomatitis, and gastrointestinal discomfort. Notably, there were statistically significant reductions in erythrocyte parameters

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June 26, 2025 No Comments

Rapamycin and Alzheimer’s Disease: Time for a Clinical Trial?

This 2019 opinion article by Matt Kaeberlein and Veronica Galvan advocates for initiating clinical trials to assess rapamycin’s efficacy in treating Alzheimer’s disease (AD). Despite compelling preclinical evidence demonstrating rapamycin’s benefits in animal models—such as reducing amyloid-beta and tau pathology, improving cognitive function, and enhancing synaptic plasticity—no human trials had

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June 26, 2025 No Comments