This study explores the potential of methylene blue (MB) to reverse the Warburg effect in glioblastoma multiforme (GBM) cells. MB treatment increased oxygen consumption and decreased lactate production, indicating a shift from glycolysis to oxidative phosphorylation. MB inhibited GBM cell proliferation and induced S-phase cell cycle arrest. Mechanistically, MB activated
This 2013 study explores the antiproliferative effects of resveratrol on gastric cancer cells through a Sirt1-dependent pathway. Resveratrol treatment caused significant G1 phase arrest and cellular senescence without inducing apoptosis. Mechanistically, it downregulated cyclin D1, CDK4, and CDK6 while upregulating p21 and p16, halting cell cycle progression. In vivo experiments
This 1999 study examined the effects of zinc on the growth of human prostate cancer cell lines LNCaP (androgen-sensitive) and PC-3 (androgen-independent). Exposure to physiological concentrations of zinc (100–1,000 ng/ml) resulted in significant growth inhibition in both cell lines, with LNCaP cells exhibiting greater sensitivity (IC50 ~100 ng/ml) compared to
This 2006 study investigates the pro-apoptotic effects of alpha-lipoic acid (α-LA) on hepatoma cell lines FaO and HepG2. Treatment with α-LA resulted in inhibited cell proliferation, decreased cyclin A expression, and increased levels of cell cycle inhibitors p21^Cip1 and p27^Kip1, leading to cell cycle arrest. Apoptosis was characterized by DNA
This 2022 study investigates ivermectin’s anticancer effects in prostate cancer, identifying FOXA1 and Ku70/Ku80 as direct targets. Ivermectin induces G0/G1 cell cycle arrest, apoptosis, and DNA damage, while suppressing androgen receptor (AR) signaling. It binds to FOXA1, reducing chromatin accessibility of AR signaling and E2F1, leading to inhibited cell proliferation.
This 2018 in vitro study evaluated the effects of methylsulfonylmethane (MSM) on prostate cancer cell lines LNCaP, PC3, and DU-145. MSM treatment led to decreased cell viability and invasiveness by inducing apoptosis and causing cell cycle arrest at the G0/G1 phase. At a concentration of 200 mM, MSM significantly reduced
This 2016 review explores betulinic acid (BA), a pentacyclic triterpene, as a multifaceted agent against breast cancer. BA inhibits cell proliferation by downregulating cyclins and topoisomerases, leading to cell cycle arrest. It induces apoptosis via the mitochondrial pathway and exhibits anti-angiogenic effects by suppressing NF-κB, Sp transcription factors, and VEGF
This preclinical study explores the anti-cancer effects of artesunate (ART), a derivative of artemisinin traditionally used for malaria, in ovarian cancer models. ART was shown to suppress growth of multiple ovarian cancer cell lines and patient-derived primary cells, and to inhibit tumor progression in xenograft mouse models. The treatment significantly
This 2016 study evaluates the inhibitory effects of epigallocatechin gallate (EGCG), a green tea polyphenol, on cancer stem-like cell (CSC) populations derived from human hepatoma and colon cancer cell lines. CSCs were enriched via sphere formation under nonadherent, serum-free conditions and exhibited higher expression of stemness markers, Nek2, and ATP-binding
This study explores the effects of bee venom on human cervical epidermoid carcinoma (Ca Ski) cells. The results show that bee venom induces cell cycle arrest and apoptosis in these cancer cells. The venom’s active components triggered the intrinsic apoptotic pathway, leading to cell death, while inhibiting cell proliferation. This
