This 2006 study investigates the pro-apoptotic effects of alpha-lipoic acid (α-LA) on hepatoma cell lines FaO and HepG2. Treatment with α-LA resulted in inhibited cell proliferation, decreased cyclin A expression, and increased levels of cell cycle inhibitors p21^Cip1 and p27^Kip1, leading to cell cycle arrest. Apoptosis was characterized by DNA
