Well Referenced

Tag: Bone Health

Testosterone deficiency and replacement: Myths and realities

This review examines the benefits and misconceptions surrounding testosterone deficiency (hypogonadism) and testosterone replacement therapy (TRT). It highlights the significant health risks associated with testosterone deficiency, such as sexual dysfunction, bone loss, and metabolic syndrome, and argues that TRT can provide substantial benefits, including improved sexual function, overall well-being, and

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June 26, 2025 No Comments

Testosterone Treatment and Fractures in Men with Hypogonadism

A randomized controlled trial published in the New England Journal of Medicine examined the effects of testosterone therapy on fracture risk in men with hypogonadism. The study included 5,204 men aged 45 to 80 with hypogonadism and cardiovascular risk factors, who were randomized to receive either testosterone gel or placebo

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June 26, 2025 No Comments

Is there a role for menopausal hormone therapy in the management of postmenopausal osteoporosis?

This narrative review, published in Osteoporosis International (2020), examines the role of menopausal hormone therapy (MHT) in managing postmenopausal osteoporosis. The study highlights that MHT provides significant anti-fracture efficacy in women not specifically selected for low bone mineral density, with benefits observed regardless of concurrent progestogen use. However, these skeletal

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June 26, 2025 No Comments

Low-dose hormone replacement therapy: effects on bone

This study examines the effects of low-dose hormone replacement therapy (HRT) on bone health in postmenopausal women. It found that low-dose HRT effectively alleviates climacteric symptoms while minimizing side effects like unscheduled bleeding. Additionally, when combined with calcium supplementation, it helps prevent bone loss, reducing the risk of osteoporosis in

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June 26, 2025 No Comments

Menopausal hormone therapy for the management of osteoporosis

This article reviews the role of menopausal hormone therapy (MHT) in preventing and managing osteoporosis in postmenopausal women. MHT has been shown to reduce bone loss and fracture risk by 20-40%, making it a highly effective treatment option for osteoporosis prevention, particularly in low-risk women. While initial concerns from the

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June 26, 2025 No Comments

Safety and benefit considerations for menopausal hormone therapy

This review examines the safety and benefits of menopausal hormone therapy (MHT), highlighting its effectiveness in alleviating vasomotor symptoms, preventing bone loss, and potentially offering cardiovascular benefits when initiated near menopause. The risk-benefit profile of MHT varies based on the timing of initiation, therapy type, and duration, with combined estrogen-progestogen

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June 26, 2025 No Comments

Estrogen and bones after menopause: a reappraisal of data and future perspectives

This review article examines the role of estrogen-based menopausal hormone therapy (MHT) in preventing postmenopausal bone loss and reducing fracture risk by exploring its dual mechanisms—suppressing osteoclast activity and enhancing osteoblast function—in a dose-dependent manner, with benefits seen even at ultra-low doses and through transdermal delivery. It discusses the clinical

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June 26, 2025 No Comments

Exogenous testosterone or testosterone with finasteride increases bone mineral density in older men with low serum testosterone

This 2004 randomized controlled trial investigated the effects of testosterone therapy, with or without finasteride, on bone mineral density (BMD) in older men with low serum testosterone levels. The study found that testosterone administration significantly increased BMD, suggesting that testosterone therapy may be beneficial for improving bone health and reducing

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June 26, 2025 No Comments

Associations of postmenopausal hormone therapy with metabolic syndrome among diabetic and non-diabetic women

The study titled “Associations of postmenopausal hormone therapy with metabolic syndrome among diabetic and non-diabetic women” (Maturitas, 2019, PMID: 30704569) is a cohort study examining the relationship between hormone therapy (HT) use and metabolic syndrome (MetS) in middle-aged postmenopausal Korean women, stratified by diabetes status. Findings indicate that HT use

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June 26, 2025 No Comments