Well Referenced

Tag: Atherosclerosis

Phytochemical and Pharmacological Activity Profile of Crataegus oxyacantha L. (Hawthorn) – A Cardiotonic Herb

This review article explores the cardiotonic herb Crataegus oxyacantha (hawthorn), highlighting its pharmacological and phytochemical properties that support cardiovascular health. It discusses how the plant’s active constituents—such as oligomeric procyanidins and flavonoids—contribute to improved coronary blood flow, exercise tolerance, and modulation of cardiac function through positive inotropic and negative chronotropic

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June 26, 2025 No Comments

Plant Polyphenols and Their Potential Benefits on Cardiovascular Health: A Review

This review article explores the cardiovascular benefits of plant-derived polyphenols, including kaempferol, quercetin, and resveratrol, highlighting their antioxidant, anti-inflammatory, and vasodilatory properties. These compounds work by reducing oxidative stress, improving endothelial function via nitric oxide production, and preventing LDL oxidation, which together help mitigate atherosclerosis, hypertension, and other cardiovascular diseases.

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June 26, 2025 No Comments

Standardized extracts from hawthorn leaves and flowers in the treatment of cardiovascular disorders–preclinical and clinical studies

This review explores the cardiovascular benefits of standardized hawthorn (Crataegus spp.) extracts, particularly in managing mild chronic heart failure. Clinical trials with over 4,000 patients have shown significant improvements, as well as vasoprotective and cardioprotective effects. Hawthorn extracts also have potential applications for treating endothelial dysfunction, atherosclerosis, coronary heart disease,

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June 26, 2025 No Comments

The Relevance of Dietary Polyphenols in Cardiovascular Protection

This review article explores the cardiovascular protective effects of dietary polyphenols, which are abundant in foods such as grapes, berries, dark chocolate, and tea. These polyphenols have demonstrated antioxidant properties that help mitigate oxidative stress, a key contributor to cardiovascular diseases. The review discusses various studies showing that polyphenols can

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June 26, 2025 No Comments

Natural Compound Resveratrol Attenuates TNF-Alpha-Induced Vascular Dysfunction in Mice and Human Endothelial Cells: The Involvement of the NF-κB Signaling Pathway

This study explored how resveratrol, a natural polyphenol, protects against TNF-α-induced vascular inflammation in human endothelial cells and mice. At physiologically relevant concentrations (as low as 1 μM), resveratrol significantly reduced monocyte adhesion, lowered expression of key inflammatory markers like MCP-1/CCL2 and ICAM-1, and inhibited NF-κB pathway activation. In mice,

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June 26, 2025 No Comments

Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease

This review discusses the concept of “inflamm-ageing,” a chronic low-grade inflammation associated with aging that contributes to vascular aging, atherosclerosis, and age-related cardiovascular diseases (CVDs). It highlights how inflammasome activation and reduced anti-inflammatory mechanisms accelerate vascular dysfunction, and it suggests that targeting these inflammatory pathways may help prevent or treat

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June 26, 2025 No Comments

Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association

This 2003 practice guideline published in Circulation (DOI: 10.1161/01.cir.0000052939.59093.45) by the CDC and AHA evaluates the clinical relevance of inflammatory markers, particularly high-sensitivity C-reactive protein (hs-CRP), in assessing cardiovascular disease (CVD) risk. It concludes that hs-CRP is a useful tool for identifying low-grade systemic inflammation and may enhance cardiovascular risk

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June 26, 2025 No Comments

Plasma C-reactive protein is associated with a pro-inflammatory and adverse plaque phenotype

This 2024 observational study published in Atherosclerosis (DOI: 10.1016/j.atherosclerosis.2024.118532) explored the relationship between plasma C-reactive protein (CRP) levels and atherosclerotic plaque characteristics. It found that elevated CRP levels were significantly associated with more inflamed and unstable plaque phenotypes, suggesting systemic inflammation plays a key role in plaque vulnerability. By linking

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June 26, 2025 No Comments

Relations of plasma high-sensitivity C-reactive protein to traditional cardiovascular risk factors

This observational study, published in Atherosclerosis (DOI: 10.1016/s0021-9150(02)00380-5), explored the relationship between plasma high-sensitivity C-reactive protein (hsCRP) levels and traditional cardiovascular risk factors in 908 participants aged 30-79. The study found that hsCRP levels were significantly higher in individuals with hypertension, diabetes, or coronary artery disease, and multiple regression analysis

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June 26, 2025 No Comments

The association between homocysteine and myocardial infarction is independent of age, sex, blood pressure, cholesterol, smoking and markers of inflammation: the Glasgow Myocardial Infarction Study

This case-control study from the Glasgow Myocardial Infarction Study evaluated the association between plasma homocysteine levels and myocardial infarction (MI) in 712 MI patients and 697 age- and sex-matched controls. Results showed that elevated homocysteine levels were significantly associated with nearly double the risk of MI (OR 1.9; 95% CI:

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June 26, 2025 No Comments