This review article discusses coronary artery calcification (CAC) and its predictive role in cardiovascular events (CVE), emphasizing its use in clinical settings to assess atherosclerotic disease progression. The article highlights the predictive value of CT imaging in quantifying both coronary and aortic valve calcification. It also reviews therapies such as
The article reviews the efficacy of chelation therapy in cardiovascular disease, particularly following myocardial infarction (MI), and highlights the potential benefits observed in specific subgroups, such as diabetic patients. It discusses findings from the Trial to Assess Chelation Therapy (TACT), which suggested some reduction in cardiovascular events but acknowledged the
This article reviews the effectiveness of chelation therapy in treating atherosclerosis, particularly in diabetic patients who have experienced a myocardial infarction (MI). Based on findings from the Trial to Assess Chelation Therapy (TACT), the therapy was shown to reduce cardiovascular events by 41% in post-MI patients with diabetes, leading to
This cohort study evaluated the role of coronary calcium scoring in predicting cardiovascular events in asymptomatic individuals, aged 50-70. Over a follow-up period of 4.3 years, the study found that participants with a coronary calcium score ≥100 had a significantly higher risk of cardiovascular events, including coronary artery disease, myocardial
The article “Role of DHEA in cardiovascular diseases” (pubmed.ncbi.nlm.nih.gov) explores the potential of dehydroepiandrosterone (DHEA) as a therapeutic agent in cardiovascular conditions such as hypertension, coronary artery disease, atherosclerosis, and pulmonary hypertension. DHEA demonstrates anti-remodeling and vasorelaxant properties, mediated through membrane and nuclear receptors, ion channels, calcium signaling, and pathways
This study explores the role of urinary 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker for oxidative stress and its association with increased risks of cancer, atherosclerosis, and diabetes. Elevated urinary 8-OHdG levels were observed in patients with various cancers, human atherosclerotic plaques, and diabetic individuals with hyperglycemia, highlighting its potential as a
This systematic review critically evaluates the discrepancies between the Women’s Health Initiative (WHI) hormone trials and previous epidemiological studies on hormone therapy (HT) in postmenopausal women. While WHI findings suggest that combined HT may increase risks of cardiovascular disease (CVD), stroke, and dementia, earlier observational studies indicated protective effects. The
This review examines the impact of hormone replacement therapy (HRT) on inflammatory biomarkers associated with cardiovascular disease in postmenopausal women. It highlights how different HRT regimens influence markers like E-selectin, monocyte chemoattractant protein-1, tumor necrosis factor-alpha, interleukin-6, transforming growth factor-alpha, and C-reactive protein (CRP). Oral conjugated estrogens increase CRP levels,
