Nutritional support for disease prevention and cellular health.
In this 2018 review published in BioFactors, Li et al. examine the anti-aging properties of resveratrol and pterostilbene, two polyphenolic compounds found in grapes and blueberries, respectively. The authors discuss how these compounds modulate key hallmarks of aging, including oxidative stress, inflammation, telomere attrition, and cellular senescence. Resveratrol and pterostilbene
This 2022 systematic review and meta-analysis by Ghanbari et al. evaluated the impact of chromium supplementation on blood pressure by analyzing data from randomized clinical trials. The study included 14 RCTs encompassing a total of 1,356 participants. The meta-analysis revealed that chromium supplementation did not result in a statistically significant
In this 2014 review published in Pharmacology & Therapeutics, Rushworth and Megson critically assess the therapeutic applications of N-acetylcysteine (NAC), emphasizing its role as a precursor to intracellular glutathione (GSH) rather than as a direct antioxidant. The authors highlight that NAC’s efficacy in conditions such as acetaminophen overdose is well-established
This 1986 double-blind, cross-over trial evaluated the efficacy of oral N-acetylcysteine (NAC) in 26 patients with primary or secondary Sjögren’s syndrome over a four-week period. Baseline assessments revealed significantly elevated salivary lactoferrin levels and decreased tear lysozyme levels compared to healthy controls. Following NAC treatment (200 mg three times daily),
This 2006 study by Wang et al. investigates the dual role of N-acetylcysteine (NAC) in acute ethanol-induced liver injury using a murine model. Female ICR mice received a single oral dose of ethanol (6 g/kg), with NAC administered either 30 minutes before (pretreatment) or 4 hours after (post-treatment) ethanol exposure.
This 1994 randomized, double-blind, placebo-controlled crossover study by Reid et al. investigated the effects of N-acetylcysteine (NAC), a nonspecific antioxidant, on muscle fatigue in healthy human volunteers. Participants received an intravenous infusion of NAC at 150 mg/kg or a placebo (5% dextrose in water) before undergoing electrically stimulated contractions of
This comprehensive 2014 review by Gupta et al. explores the therapeutic applications of zinc in dermatology, encompassing both topical and oral formulations. Zinc’s anti-inflammatory, antioxidant, immunomodulatory, and antimicrobial properties underpin its efficacy in various skin conditions. In acne vulgaris, oral zinc sulfate and gluconate have demonstrated benefits, particularly in inflammatory
This review article discusses the potential benefits of early nutritional interventions using zinc, selenium, and vitamin D to enhance antiviral resistance, particularly in the context of COVID-19. The authors highlight that deficiencies in these micronutrients can impair immune function and increase susceptibility to viral infections. Zinc is noted for its
This review article explores the role of essential micronutrients—specifically vitamins A, C, D, E, B-complex, and minerals like zinc, selenium, iron, and copper—in supporting immune function against SARS-CoV-2. The authors discuss how deficiencies in these nutrients can impair immune responses, leading to increased susceptibility to infections. Vitamin D is highlighted
This review article explores the potential roles of vitamins D, C, E, zinc, selenium, and omega-3 fatty acids in enhancing immune function, particularly in the context of COVID-19. The authors discuss how deficiencies in these nutrients can impair immune responses and increase susceptibility to infections. Vitamin D is highlighted for
