Well Referenced

Category: Metabolic & Endocrine Health

Hormonal regulation, blood sugar control, and metabolic balance.

Safety Evaluation of α-Lipoic Acid Supplementation: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Studies

The study titled “Safety Evaluation of α-Lipoic Acid Supplementation: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Studies” (Antioxidants (Basel), 2020, PMID: 33086555) assessed the safety of α-lipoic acid (ALA) supplementation by analyzing data from 71 randomized placebo-controlled trials involving 4,749 participants (2,558 receiving ALA and 2,294 on placebo).

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June 26, 2025 No Comments

NAD⁺ and Sirtuins in Aging and Disease

This review explores the role of nicotinamide adenine dinucleotide (NAD⁺) and sirtuins in aging and disease, highlighting how declining NAD⁺ levels impair nuclear and mitochondrial function, contributing to age-related conditions such as neurodegenerative diseases. NAD⁺ is a critical coenzyme in redox reactions and regulates enzymes involved in metabolism, circadian rhythms,

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June 26, 2025 No Comments

The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid: the SYDNEY trial

The study titled “The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid: the SYDNEY trial” (Diabetes Care, 2003, PMID: 12610036) is a randomized controlled trial investigating the effects of alpha-lipoic acid (ALA) on diabetic polyneuropathy. Involving 120 patients with type 2 diabetes and symptomatic polyneuropathy, participants received either

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June 26, 2025 No Comments

Intestinal absorption of water-soluble vitamins in health and disease

The article “Intestinal absorption of water-soluble vitamins in health and disease” by Hamid M. Said, published in the Biochemical Journal in 2011 (PMID: 21749321), is a comprehensive review that delves into the mechanisms and regulatory processes involved in the intestinal absorption of water-soluble vitamins, including ascorbate, biotin, folate, niacin, pantothenic

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June 26, 2025 No Comments

Treatment of Symptomatic Diabetic Polyneuropathy With the Antioxidant Alpha-Lipoic Acid: A Meta-Analysis

The meta-analysis titled “Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis” (Diabet Med, 2004, PMID: 14984445) evaluated the efficacy and safety of intravenous alpha-lipoic acid (600 mg/day) over three weeks in diabetic patients with symptomatic polyneuropathy. Analyzing data from four randomized, double-masked, placebo-controlled trials (n=1,258), the

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June 26, 2025 No Comments

Absorption of Oral Progesterone is Influenced by Vehicle and Particle Size

This clinical trial examined how oral progesterone absorption is influenced by formulation, specifically particle size and vehicle type. Seven subjects received a 200 mg dose of progesterone in different formulations: plain milled, micronized, plain milled in oil, micronized in oil, and micronized in enteric-coated capsules. Serum progesterone levels were measured

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June 26, 2025 No Comments

α-lipoic acid in patients with autosomal dominant polycystic kidney disease

The study titled “α-lipoic acid in patients with autosomal dominant polycystic kidney disease” (Nutrition, 2020, PMID: 31790890) investigated the effects of α-lipoic acid (ALA) supplementation on systemic inflammation, endothelial dysfunction, and atherosclerosis in patients with autosomal dominant polycystic kidney disease (ADPKD). In a six-month intervention, 33 patients received 1.6 g

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June 26, 2025 No Comments