Well Referenced

Category: Metabolic & Endocrine Health

Hormonal regulation, blood sugar control, and metabolic balance.

GH responses to intravenous bolus infusions of GH-releasing hormone and GH-releasing peptide-2 separately and in combination in adult volunteers

This randomized controlled trial evaluated the effects of intravenous administration of growth hormone-releasing hormone (GHRH1-29NH2) and growth hormone-releasing peptide-2 (GHRP-2), individually and combined, on growth hormone (GH) secretion in healthy adult males. GHRP-2 alone significantly increased GH secretion (AUC: 6205.1 ± 3216.9 mU/l·min) compared to GHRH alone (AUC: 2061.2 ±

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June 26, 2025 No Comments

Plasma GH responses to human GHRH-antagonist in normal subjects

This clinical trial investigated the effects of a growth hormone-releasing hormone (GHRH) antagonist on plasma growth hormone (GH) levels in healthy individuals. The results showed that the GHRH antagonist significantly reduced GH secretion, demonstrating the pivotal role of endogenous GHRH in regulating GH release. This finding suggests that GHRH antagonists

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June 26, 2025 No Comments

Growth hormone (GH) profiles in response to continuous subcutaneous infusion of GH-releasing hormone(1-29)-NH2 in children with GH deficiency

This randomized controlled trial investigated the effects of continuous subcutaneous infusion of GH-releasing hormone(1-29)-NH2 (GHRH1-29-NH2) in children with growth hormone deficiency (GHD). The treatment successfully restored physiological growth hormone (GH) secretion patterns, leading to increased insulin-like growth factor 1 (IGF-1) levels and improved growth velocity. These results suggest that GHRH1-29-NH2

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June 26, 2025 No Comments

Polyethylene glycol-conjugated growth hormone-releasing hormone is long acting and stimulates GH in healthy young and elderly subjects

This study evaluated the pharmacokinetics and efficacy of polyethylene glycol (PEG)-conjugated growth hormone-releasing hormone (GHRH) in healthy young and elderly subjects. The results showed that PEG-GHRH has an extended half-life compared to native GHRH, leading to prolonged GH secretion in both age groups. The GH response was dose-dependent, with higher

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June 26, 2025 No Comments

Growth hormone (GH)-releasing effects of synthetic peptide GH-releasing peptide-2 and GH-releasing hormone (1-29)NH2 in children with GH insufficiency and idiopathic short stature

This randomized controlled trial investigated the effects of GHRH1-29NH2 and GHRP-2, both individually and in combination, on growth hormone (GH) release in children with growth hormone insufficiency and idiopathic short stature. The results indicated that while both peptides effectively stimulated GH secretion, the combination of GHRH1-29NH2 and GHRP-2 had a

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June 26, 2025 No Comments

Quantitative growth hormone secretion and final adult height

This study examined the relationship between quantitative growth hormone (GH) secretion and final adult height in 40 healthy postpubertal men, aged 18-27 years. The study found no significant differences in GH responses or secretion patterns between individuals with tall and short stature, suggesting that GH secretion levels do not play

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June 26, 2025 No Comments

Growth hormone (GH)-releasing peptide-6 requires endogenous hypothalamic GH-releasing hormone for maximal GH stimulation

This study examined the effects of growth hormone-releasing peptide-6 (GHRP-6) on growth hormone (GH) secretion in healthy male volunteers, demonstrating that GHRP-6 significantly stimulates GH release, with its effects largely dependent on the presence of endogenous growth hormone-releasing hormone (GHRH). When participants were pretreated with a GHRH antagonist, the GH

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June 26, 2025 No Comments

Stimulation of growth hormone secretion with human growth hormone releasing factors (GRF1-44, GRF1-40, GRF1-29) in normal subjects

This clinical trial investigated the effects of synthetic growth hormone-releasing factors (GRF1-44, GRF1-40, and GRF1-29) on growth hormone (GH) secretion in healthy adult males. The study demonstrated that all three GRF analogs significantly increased GH secretion, with GRF1-44 producing the most substantial response. The findings suggest that synthetic GRFs can

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June 26, 2025 No Comments

Growth hormone and prolactin secretion after growth hormone-releasing hormone administration, in anorexia nervosa patients, normal controls and tamoxifen-pretreated volunteers

This study assessed the effects of growth hormone-releasing hormone (GHRH) on growth hormone (GH) and prolactin (PRL) secretion in women with anorexia nervosa, normal controls, and tamoxifen-pretreated volunteers. Results showed that GHRH administration induced a GH peak in both anorexia nervosa patients and controls, suggesting that the hypothalamic-pituitary axis remains

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June 26, 2025 No Comments

The effect of calcitonin on growth hormone secretion in man

This clinical trial investigated the effects of human calcitonin on growth hormone (GH) secretion in healthy male subjects. The study found that calcitonin suppressed spontaneous GH surges and reduced GH responses to both insulin-induced hypoglycemia and growth hormone-releasing hormone (GHRH). Additionally, calcitonin led to a transient increase in plasma prolactin

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June 26, 2025 No Comments