Well Referenced

Category: Metabolic & Endocrine Health

Hormonal regulation, blood sugar control, and metabolic balance.

Growth hormone-releasing hormone and its analogues in health and disease

This review explores the diverse biological effects of growth hormone-releasing hormone (GHRH) and its analogues, highlighting their potential therapeutic applications across various medical conditions. GHRH and its analogues stimulate cell growth, tissue repair, and wound healing, regulate apoptosis, modulate inflammation and immune responses, and offer neuroprotective effects, making them promising

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June 26, 2025 No Comments

The interaction between clonidine and growth hormone releasing hormone in the stimulation of growth hormone secretion in man

This randomized controlled trial (PMID: 2147600) investigated the interaction between clonidine and GHRH on GH secretion in 6 healthy adult males. Peak GH concentrations were significantly higher when GHRH was given during rising GH levels (52.9 mU/L) compared to falling (27.5 mU/L) or stable (20.6 mU/L) levels (P=0.004). Clonidine-induced GH

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June 26, 2025 No Comments

Growth hormone-releasing hormone receptor (GHRH-R) and its role in cardiac repair

This review article explores the structure, signaling pathways, and therapeutic potential of the growth hormone-releasing hormone receptor (GHRH-R) and its splice variants (SVs). GHRH-R is primarily expressed in the pituitary gland, and its activation triggers growth hormone secretion through cAMP-dependent pathways. The review also highlights the role of GHRH analogs

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June 26, 2025 No Comments

The relative roles of continuous growth hormone-releasing hormone (GHRH(1-29)NH2) and intermittent somatostatin(1-14)(SS) in GH pulse generation: studies in normal and post-cranial irradiated individuals

This randomized controlled trial (PMID: 10594518) evaluated how continuous GHRH(1-29)NH2 infusion and intermittent somatostatin withdrawal influenced GH pulse generation in n=12 long-term survivors and n=6 short-term survivors of childhood brain tumors post-cranial irradiation, compared to n=9 and n=6 healthy matched controls. In healthy adults, pulsatile GH secretion persisted under GHRH

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June 26, 2025 No Comments

Growth response to growth hormone-releasing hormone(1-29)-NH2 compared with growth hormone

This study compared the effectiveness of growth hormone-releasing hormone (GHRH(1-29)-NH₂) with standard growth hormone (GH) therapy in promoting growth in children with hypothalamic growth hormone deficiency (GHD). High-dose GHRH(1-29)-NH₂ significantly increased height velocity, comparable to GH treatment, but had no effect on bone age development. GHRH(1-29)-NH₂ did not induce GH

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June 26, 2025 No Comments

Influence of dopaminergic, adrenergic and cholinergic blockade and TRH administration on GH responses to GRF 1-29

This study investigated the effects of dopaminergic, adrenergic, and cholinergic blockade, along with TRH administration, on growth hormone (GH) responses to growth hormone-releasing factor (GRF) 1-29. It was found that these neurotransmitter systems modulate GH secretion in response to GRF, and TRH administration also influenced GH release. The study highlights

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June 26, 2025 No Comments

Interaction of the growth hormone releasing peptide hexarelin with somatostatin

This study investigated the interaction between hexarelin, a growth hormone-releasing peptide, and somatostatin, which inhibits growth hormone (GH) release. The results showed that somatostatin and hexarelin counteract each other’s effects on GH secretion, with somatostatin inhibiting and hexarelin stimulating GH release. The combination of hexarelin with growth hormone-releasing hormone (GHRH)

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June 26, 2025 No Comments

Intranasal administration of growth hormone-releasing hormone(1-29)-NH2 in children with growth hormone deficiency: effects on growth hormone secretion and growth

This study explored the efficacy of intranasal growth hormone-releasing hormone (GHRH(1-29)-NH₂) in stimulating growth hormone secretion and improving growth in children with growth hormone deficiency. The results showed that intranasal GHRH(1-29)-NH₂ significantly increased GH secretion and improved linear growth, suggesting it could be a viable, non-invasive alternative to traditional GH

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June 26, 2025 No Comments

Lack of effect of muscarinic cholinergic blockade on the GH responses to GRF 1-29 and TRH in acromegalic subjects

This study investigated the role of muscarinic cholinergic receptors in regulating growth hormone (GH) secretion in acromegalic patients. The trial involved eight subjects who received GH-releasing factor (GRF 1-29) and thyrotropin-releasing hormone (TRH) tests, with and without pirenzepine, a muscarinic antagonist. The results showed that muscarinic cholinergic blockade did not

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June 26, 2025 No Comments

Low-dose growth hormone-releasing hormone tests: a dose-response study

This clinical trial evaluated the dose-response relationship of GHRH(1-29)NH2 in stimulating growth hormone (GH) secretion in healthy adult males. The study found that both 10- and 100-microgram doses of GHRH(1-29)NH2 resulted in significant GH responses, with the 10-microgram dose eliciting a slower decline in GH levels, suggesting a more prolonged

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June 26, 2025 No Comments