Hormonal regulation, blood sugar control, and metabolic balance.
The article examines the growing use of testosterone therapy in women, especially during perimenopause and menopause, for managing symptoms such as sexual dysfunction and osteoporosis. It discusses the safety and potential benefits of testosterone, advocating for FDA approval of testosterone treatments for women. The author highlights the therapy’s role in
The study titled “Lipoic Acid Decreases the Viability of Breast Cancer Cells and Activity of PTP1B and SHP2” (Anticancer Res. 2017 Jun;37(6):2893-2898. doi: 10.21873/anticanres.11642) is an in vitro study examining the effects of alpha-lipoic acid (ALA) and its reduced form, dihydrolipoic acid (DHLA), on breast cancer cells. The research found
This article reviews the binding of testosterone to circulating proteins, focusing on its role in androgen disorders and its implications for clinical management, including testosterone replacement therapy. It highlights the importance of distinguishing between free and bound testosterone for accurate diagnosis and treatment. The review stresses that only free testosterone
This in vitro study, published in Archives of Toxicology (2015, PMID: 25526924), examined the effects of alpha-lipoic acid (LA) on colorectal cancer (CRC) cells, demonstrating that LA induces cell death regardless of p53 status and enhances the cytotoxic effects of 5-fluorouracil (5-FU). Conducted on various CRC cell lines, the study
The study titled “Safety Evaluation of α-Lipoic Acid Supplementation: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Studies” (Antioxidants (Basel), 2020, PMID: 33086555) assessed the safety of α-lipoic acid (ALA) supplementation by analyzing data from 71 randomized placebo-controlled trials involving 4,749 participants (2,558 receiving ALA and 2,294 on placebo).
This randomized controlled trial examined the effects of Nitrosigine® (arginine and silicon) and citrulline malate (CM) on endothelial-dependent vasodilation in 24 healthy, physically active adults. Participants consumed either 1.5 g of Nitrosigine®, 8 g of CM, or a placebo, with flow-mediated dilation (FMD) measured before and 60 minutes post-ingestion. Both
The 2017 retrospective observational study titled “Safety of oral alpha-lipoic acid treatment in pregnant women,” published in the European Review for Medical and Pharmacological Sciences, investigated the safety of administering 600 mg of alpha-lipoic acid daily to 610 pregnant women for at least 7 weeks during gestation. The study found
This review explores the role of nicotinamide adenine dinucleotide (NAD⁺) and sirtuins in aging and disease, highlighting how declining NAD⁺ levels impair nuclear and mitochondrial function, contributing to age-related conditions such as neurodegenerative diseases. NAD⁺ is a critical coenzyme in redox reactions and regulates enzymes involved in metabolism, circadian rhythms,
The study titled “The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid: the SYDNEY trial” (Diabetes Care, 2003, PMID: 12610036) is a randomized controlled trial investigating the effects of alpha-lipoic acid (ALA) on diabetic polyneuropathy. Involving 120 patients with type 2 diabetes and symptomatic polyneuropathy, participants received either
The article “Intestinal absorption of water-soluble vitamins in health and disease” by Hamid M. Said, published in the Biochemical Journal in 2011 (PMID: 21749321), is a comprehensive review that delves into the mechanisms and regulatory processes involved in the intestinal absorption of water-soluble vitamins, including ascorbate, biotin, folate, niacin, pantothenic
