This randomized controlled trial (PMID: 2147600) investigated the interaction between clonidine and GHRH on GH secretion in 6 healthy adult males. Peak GH concentrations were significantly higher when GHRH was given during rising GH levels (52.9 mU/L) compared to falling (27.5 mU/L) or stable (20.6 mU/L) levels (P=0.004). Clonidine-induced GH
