Well Referenced

Category: Brain, Neurology & Mental Health

Mental wellness, brain performance, and neuroprotection strategies.

α-Lipoic Acid Has the Potential to Normalize Copper Metabolism, Which Is Dysregulated in Alzheimer’s Disease

This experimental study evaluates α-lipoic acid (LA) as a modulator of copper homeostasis in Alzheimer’s disease (AD). Through in vitro and in vivo models—including SH-SY5Y neuronal cells and Drosophila melanogaster expressing human Aβ—LA was found to promote intracellular copper uptake, potentially reversing the copper dyshomeostasis observed in AD. Supplementation with

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June 26, 2025 No Comments

High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial

This randomized, double-blind, placebo-controlled trial assessed the efficacy of high-dose B vitamin supplementation (folic acid 5 mg, vitamin B6 25 mg, and vitamin B12 1 mg daily) in slowing cognitive decline among 409 individuals with mild to moderate Alzheimer’s disease over 18 months. Despite significant reductions in plasma homocysteine levels

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June 26, 2025 No Comments

Challenges and Opportunities of Metal Chelation Therapy in Trace Metals Overload-Induced Alzheimer’s Disease

This 2023 review examines the role of trace metal dyshomeostasis—particularly involving copper (Cu), zinc (Zn), and iron (Fe)—in Alzheimer’s disease (AD) pathogenesis. It highlights how abnormal accumulation of these metals contributes to amyloid-β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, and neuroinflammation. The study evaluates various chelating agents, such as deferoxamine,

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June 26, 2025 No Comments

Supplemental thiamine as a practical, potential way to prevent Alzheimer’s disease from commencing

This article proposes that thiamine (vitamin B1) supplementation may serve as a preventive strategy against Alzheimer’s disease (AD) in elderly individuals who are cognitively normal but exhibit amyloid or tau deposition. Thiamine deficiency is common in older adults and is associated with several AD-related pathologies, including synaptic hypometabolism, mitochondrial dysfunction,

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June 26, 2025 No Comments

Alzheimer’s disease and environmental exposure to lead: the epidemiologic evidence and potential role of epigenetics

This review explores the potential link between environmental lead (Pb) exposure and late-onset Alzheimer’s disease (LOAD), emphasizing the role of epigenetic mechanisms. Epidemiological studies indicate that cumulative lifetime Pb exposure is associated with accelerated cognitive decline in adults. Animal models suggest that early-life Pb exposure may lead to epigenetic modifications,

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June 26, 2025 No Comments

Novel Nutraceutical Compounds in Alzheimer Prevention

This review highlights the potential of nutraceuticals—bioactive compounds derived from food sources—in preventing Alzheimer’s disease (AD). The authors discuss how certain nutraceuticals, such as quercetin, biocurcumin, rosmarinic acid, Andean shilajit, anthocyanidins, and hydroxytyrosol, exhibit antioxidant, anti-inflammatory, and anti-amyloid properties. These compounds may interfere with AD pathogenesis by reducing oxidative stress,

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June 26, 2025 No Comments

Relationship between androgen deficiency and memory impairment in aging and Alzheimer’s disease

This review explores the association between androgen deficiency—specifically reductions in testosterone (T), dehydroepiandrosterone (DHEA), and its sulfate (DHEA-S)—and memory impairment in aging and Alzheimer’s disease (AD). It highlights that hypoandrogenism correlates with cognitive decline, potentially due to its influence on tau protein hyperphosphorylation, a hallmark of AD pathology. While animal

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June 26, 2025 No Comments