Well Referenced

Category: Aesthetic & Dermatology

Treatments, techniques, and research for skin, hair, and aesthetic health.

Use of curcuminoids in a cohort of patients with oral lichen planus, an autoimmune disease

This randomized controlled trial investigated the use of curcuminoids, compounds derived from turmeric, in patients with oral lichen planus (OLP), a chronic autoimmune condition affecting the oral mucosa. The study found that curcuminoid treatment significantly reduced OLP symptoms compared to baseline, with no major adverse effects reported, indicating good tolerability.

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June 26, 2025 No Comments

The influence of low dose finasteride, a type II 5α-reductase inhibitor, on circulating neuroactive steroids

This observational study investigated the effects of low-dose finasteride (1 mg/day for 4 months) on circulating neuroactive steroids in 12 men with premature androgenetic alopecia. The treatment led to a gradual decrease in several 5α-reduced and 5-ene steroids, including DHT, allopregnanolone, pregnenolone, and others. These changes, particularly the reduction in

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June 26, 2025 No Comments

Androgenetic alopecia: an evidence-based treatment update

This 2014 systematic review published in the American Journal of Clinical Dermatology (PMID: 24848508) provides an evidence-based update on treatments for androgenetic alopecia (AGA) in both men and women. The review concludes that oral finasteride (1 mg/day) and topical minoxidil (2% or 5%) are the most effective and well-supported options,

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June 26, 2025 No Comments

Topical Minoxidil: Systematic Review and Meta-Analysis of Its Efficacy in Androgenetic Alopecia

This meta-analysis evaluated the efficacy of topical minoxidil in treating androgenetic alopecia (AGA), demonstrating that it significantly increased both total and nonvellus hair counts compared to placebo. Results showed notable improvements in hair growth as measured by both investigators and self-reports, with relative risks of 2.28 and 1.56, respectively. The

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June 26, 2025 No Comments

Long-term safety and efficacy of dutasteride in the treatment of male patients with androgenetic alopecia

This 52-week observational study evaluated the long-term safety and efficacy of dutasteride 0.5 mg daily in 120 Japanese men with androgenetic alopecia (AGA). The results showed that dutasteride was generally well tolerated, with mild adverse events such as nasopharyngitis, erectile dysfunction, and decreased libido occurring in 17% of participants, none

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June 26, 2025 No Comments

Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss

This 2016 observational study published in the Journal of Clinical Endocrinology & Metabolism (PMID: 27662439) evaluated men who reported persistent sexual symptoms after discontinuing finasteride for androgenetic alopecia. The study found no evidence of ongoing androgen deficiency or 5α-reductase inhibition, but symptomatic users displayed depressed mood and functional MRI changes

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June 26, 2025 No Comments

Surgical Management for Hair Restoration: A Review of Contemporary Techniques

This 2023 review article published in Aesthetic Plastic Surgery (DOI: 10.1007/s00266-023-03391-2, PMID: 37193885) explores contemporary surgical techniques for hair restoration, including follicular unit excision (FUE), follicular unit transplantation (FUT), local flaps, and scalp reduction procedures. While local flaps are commonly used for post-traumatic or reconstructive cases, FUE and FUT are

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June 26, 2025 No Comments

Finasteride in the treatment of alopecia

Finasteride, a 5α-reductase inhibitor, is approved for treating male pattern baldness (androgenetic alopecia) and works by reducing levels of dihydrotestosterone (DHT), a hormone linked to hair loss. Taken orally at 1 mg/day, it significantly improves hair growth and density by preventing the miniaturization of hair follicles. While generally well-tolerated, the

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June 26, 2025 No Comments