This 2015 randomized, evaluator-blinded, placebo-controlled trial assessed the efficacy of autologous platelet-rich plasma (PRP) injections in treating male pattern hair loss. In a half-head design, 23 patients received PRP on one side of the scalp and placebo on the other, with three treatments administered at 30-day intervals. Results demonstrated a
This 2011 animal study titled “Ozonated sesame oil enhances cutaneous wound healing in SKH1 mice” (Wound Repair and Regeneration, DOI: [10.1111/j.1524-475X.2010.00649.x*) examined the impact of three different peroxide levels of ozonated sesame oil on skin wound healing in hairless SKH1 mice. The findings showed that moderately ozonated sesame oil (peroxide
This 2010 systematic review titled “Ozone and ozonated oils in skin diseases: a review” (Mediators of Inflammation, DOI: [10.1155/2010/610418*) discusses the chemistry, therapeutic potential, and formulation considerations of ozonated oils for dermatological use. Highlighting the formation of ozonides and peroxides through the reaction of ozone with unsaturated triglycerides, the review
This 2005 review titled “The Dual Action of Ozone on the Skin” (British Journal of Dermatology, DOI: [10.1111/j.1365-2133.2005.06939.x*) discussed ozone’s paradoxical effects on the skin, showing that while chronic ozone exposure depletes skin antioxidants and triggers inflammation, controlled therapeutic ozone applications—such as full-body exposure in ozone cabins or topical ozonated
This 2009 animal study titled “Therapeutic Effects of Topical Application of Ozone on Acute Cutaneous Wound Healing” (Journal of Korean Medical Science, DOI: [10.3346/jkms.2009.24.3.368*) evaluated the effects of ozonated olive oil on wound healing in guinea pigs. The ozone-treated group showed significantly smaller wound sizes, increased collagen deposition, greater fibroblast
This 2024 retrospective study titled “Efficacy and Safety of Sequential Treatment with Botulinum Toxin Type A, Fractional CO₂ Laser, and Topical Growth Factor for Hypertrophic Scar Management” (Scientific Reports, DOI: [10.1038/s41598-024-78094-y]*) analyzed 82 patients treated sequentially with BoNT-A, fractional CO₂ laser, and topical growth factors for hypertrophic scars. Significant improvements
This systematic review published in Medical Gas Research (2020) analyzes 28 studies evaluating the efficacy of ozonated oil in treating various acute and chronic inflammatory skin conditions, such as burns, diabetic foot ulcers, and aphthous ulcers. The key findings show that ozonated oil exhibits strong antimicrobial, anti-inflammatory, and regenerative effects
This 2019 systematic review titled “Ozonated Oils and Cutaneous Wound Healing” (Current Pharmaceutical Design, DOI: [10.2174/1381612825666190702100504*) examined numerous experimental and clinical studies on the use of ozonated oils in wound healing. The findings highlight ozonated oils’ potent antimicrobial properties (bactericidal, antiviral, and antifungal), as well as their ability to modulate
This 2020 systematic review titled “Ozonated Oils as Antimicrobial Systems in Topical Applications. Their Characterization, Current Applications, and Advances in Improved Delivery Techniques” (Molecules, DOI: [10.3390/molecules25020334*) explores the chemical properties, antimicrobial mechanisms, and evolving applications of ozonated oils in medical, cosmetic, and textile fields. The review highlights that ozonated oils
This 2013 animal study titled “Ozonated oils as functional dermatological matrices: effects on the wound healing process using SKH1 mice” (International Journal of Pharmaceutics, DOI: [10.1016/j.ijpharm.2013.09.039*) evaluated the wound healing effects of ozonated olive, sesame, and linseed oils with identical ozonation levels on SKH1 mice. Ozonated sesame oil significantly accelerated
