The influence of low dose finasteride, a type II 5α-reductase inhibitor, on circulating neuroactive steroids

This observational study investigated the effects of low-dose finasteride (1 mg/day for 4 months) on circulating neuroactive steroids in 12 men with premature androgenetic alopecia. The treatment led to a gradual decrease in several 5α-reduced and 5-ene steroids, including DHT, allopregnanolone, pregnenolone, and others. These changes, particularly the reduction in