Well Referenced

Tag: dihydrotestosterone

Endogenous Sex Hormones and Prostate Cancer: A Collaborative Analysis of 18 Prospective Studies

This 2008 collaborative meta-analysis by the Endogenous Hormones and Prostate Cancer Collaborative Group pooled data from 18 prospective studies, encompassing 3,886 men with incident prostate cancer and 6,438 controls, to assess the relationship between circulating endogenous sex hormones and prostate cancer risk. The analysis found no significant associations between prostate

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June 26, 2025 No Comments

The influence of low dose finasteride, a type II 5α-reductase inhibitor, on circulating neuroactive steroids

This observational study investigated the effects of low-dose finasteride (1 mg/day for 4 months) on circulating neuroactive steroids in 12 men with premature androgenetic alopecia. The treatment led to a gradual decrease in several 5α-reduced and 5-ene steroids, including DHT, allopregnanolone, pregnenolone, and others. These changes, particularly the reduction in

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June 26, 2025 No Comments

Long-term treatment with finasteride 1 mg decreases the likelihood of developing further visible hair loss in men with androgenetic alopecia (male pattern hair loss)

This randomized controlled trial evaluated the long-term efficacy of finasteride 1 mg/day in preventing further visible hair loss in men with androgenetic alopecia (AGA). Analyzing data from 1,553 participants across two Phase III studies, the results showed that daily finasteride use led to a 93% reduction in the 5-year likelihood

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June 26, 2025 No Comments

The effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone concentrations in patients with male pattern baldness

This randomized controlled trial investigated the effect of finasteride, a 5 alpha-reductase inhibitor, on scalp skin testosterone and dihydrotestosterone (DHT) levels in men with male pattern baldness. Over 28 days, participants taking 5 mg/day of finasteride experienced a significant reduction in scalp DHT levels (from 6.40 to 3.62 pmol/g) and

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June 26, 2025 No Comments

The effects of finasteride on scalp skin and serum androgen levels in men with androgenetic alopecia

This randomized controlled trial investigated the effects of finasteride on scalp and serum dihydrotestosterone (DHT) levels in men with androgenetic alopecia. Involving 249 male participants over 42 days, the study demonstrated that finasteride, a 5α-reductase type 2 inhibitor, significantly reduced both scalp and serum DHT in a dose-dependent manner—scalp DHT

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June 26, 2025 No Comments

Monoamines and neurosteroids in sexual function during induced hypogonadism in healthy men

The study “Monoamines and neurosteroids in sexual function during induced hypogonadism in healthy men” examined the effects of induced hypogonadism on sexual function and its relationship with cerebrospinal fluid (CSF) levels of neurosteroids and monoamine metabolites. In this comparative study, healthy male volunteers received the gonadotropin-releasing hormone agonist leuprolide acetate

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June 26, 2025 No Comments