Well Referenced

Tag: vitamin B12

Use of Oral Supplements and Topical Adjuvants for Isotretinoin-Associated Side Effects: A Narrative Review

This 2024 narrative review evaluates the efficacy and safety of various oral supplements and topical adjuvants in mitigating mucocutaneous and musculoskeletal side effects associated with isotretinoin therapy. Oral supplements such as omega-3 fatty acids, vitamin E, folic acid with vitamin B12, antihistamines, L-carnitine, biotin, and combination supplements were found to

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June 26, 2025 No Comments

Association of vitamin B12 with obesity, overweight, insulin resistance and metabolic syndrome, and body fat composition; primary care-based study

This 2013 cross-sectional study assessed 976 adults (414 obese, 212 overweight, 351 controls) in a primary care setting to examine the relationship between vitamin B12 levels and metabolic parameters. Findings revealed significantly lower vitamin B12 levels in obese (178.9 ± 25.2 pg/mL) and overweight (219.8 ± 78.5 pg/mL) individuals compared

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June 26, 2025 No Comments

High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial

This randomized, double-blind, placebo-controlled trial assessed the efficacy of high-dose B vitamin supplementation (folic acid 5 mg, vitamin B6 25 mg, and vitamin B12 1 mg daily) in slowing cognitive decline among 409 individuals with mild to moderate Alzheimer’s disease over 18 months. Despite significant reductions in plasma homocysteine levels

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June 26, 2025 No Comments

Metabolic and endocrine factors in mild cognitive impairment

This 2010 review examines the influence of metabolic and endocrine factors on mild cognitive impairment (MCI). It highlights chronic kidney disease as a newly identified independent risk factor for MCI. The review discusses the potential benefits of testosterone substitution in individuals with low testosterone levels, though routine screening is not

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June 26, 2025 No Comments

Preventive health care, 2000 update: screening and management of hyperhomocysteinemia for the prevention of coronary artery disease events. The Canadian Task Force on Preventive Health Care

This 2000 guideline by the Canadian Task Force on Preventive Health Care evaluates the role of hyperhomocysteinemia in coronary artery disease (CAD). Elevated total homocysteine (tHcy) levels are associated with increased CAD risk, with prevalence ranging from 5–10% in the general population and up to 30–40% in the elderly. Despite

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June 26, 2025 No Comments

Association of MTHFR C677T, MTHFRA1298C, and MTRRA66G Gene Polymorphisms with Hyperhomocysteinemia and Its Modulation by the Combined Effect of Vitamin B12 and Folate in Chinese Population with Hypertension

This study examined the association between MTHFR C677T, MTHFR A1298C, and MTRR A66G gene polymorphisms with hyperhomocysteinemia in a hypertensive Chinese population, and how these polymorphisms could be modulated by vitamin B12 and folate supplementation. The results showed that these genetic variations were linked to elevated homocysteine levels, and supplementation

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June 26, 2025 No Comments

The importance of folate, vitamins B6 and B12 for the lowering of homocysteine concentrations for patients with recurrent pregnancy loss and MTHFR mutations

This study investigated the effects of supplementation with methylfolate, vitamin B6, and vitamin B12 on plasma homocysteine levels and pregnancy outcomes in women with recurrent pregnancy loss (RPL) and MTHFR mutations. Sixteen women with RPL and confirmed MTHFR mutations were randomized to receive the supplements for a year, resulting in

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June 26, 2025 No Comments