This 2007 randomized controlled trial titled "Sciatica: Treatment with Intradiscal and Intraforaminal Injections of Steroid and Oxygen-Ozone versus Steroid Only" (Radiology, DOI: [10.1148/radiol.2423051934*) compared the effectiveness of standard steroid/anesthetic injections with and without the addition of oxygen-ozone (O₂-O₃) therapy in 159 patients suffering from radicular pain due to acute lumbar
