Safety and efficacy of intravenous iron therapy in reducing requirement for allogeneic blood transfusion: systematic review and meta-analysis of randomised clinical trials

This systematic review and meta-analysis evaluated the efficacy and safety of intravenous (IV) iron therapy in reducing the need for allogeneic red blood cell transfusions. The analysis included 72 randomized controlled trials encompassing 10,605 patients. Findings demonstrated that IV iron therapy significantly increased hemoglobin levels (standardized mean difference of 6.5