This observational study compared the safety and efficacy of enclomiphene versus clomiphene in treating hypogonadal men, demonstrating that enclomiphene significantly increased testosterone levels (median increase of 166 ng/dL vs. 98 ng/dL with clomiphene) while reducing estradiol levels (5.92 pg/mL decrease vs. 17.50 pg/mL increase with clomiphene, P=0.001). Enclomiphene also had
