Well Referenced

Tag: selective estrogen receptor modulators

Effectiveness of Adding Everolimus to the First-line Treatment of Advanced Breast Cancer in Premenopausal Women Who Experienced Disease Progression While Receiving Selective Estrogen Receptor Modulators: A Phase 2 Randomized Clinical Trial

This 2021 phase 2 randomized clinical trial (MIRACLE study) assessed the benefit of adding everolimus to letrozole in premenopausal women with hormone receptor-positive, ERBB2-negative advanced breast cancer who had progressed on selective estrogen receptor modulators (SERMs). A total of 199 patients were randomized to receive either everolimus (10 mg/day) with

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June 26, 2025 No Comments

Preserving fertility in the hypogonadal patient: an update

This 2015 review addresses the challenge of managing hypogonadism in men desiring fertility preservation. Exogenous testosterone therapy can suppress the hypothalamic-pituitary-gonadal axis, leading to impaired spermatogenesis and potential azoospermia. The authors highlight alternative treatments, such as human chorionic gonadotropin (hCG), which can stimulate endogenous testosterone production and maintain intratesticular testosterone

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June 26, 2025 No Comments

Safety and efficacy of enclomiphene and clomiphene for hypogonadal men

This observational study compared the safety and efficacy of enclomiphene versus clomiphene in treating hypogonadal men, demonstrating that enclomiphene significantly increased testosterone levels (median increase of 166 ng/dL vs. 98 ng/dL with clomiphene) while reducing estradiol levels (5.92 pg/mL decrease vs. 17.50 pg/mL increase with clomiphene, P=0.001). Enclomiphene also had

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June 26, 2025 No Comments