Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study

This randomized controlled trial compared the efficacy and safety of curcumin (500 mg three times daily) versus diclofenac (50 mg twice daily) in treating knee osteoarthritis (OA). Both treatments significantly improved pain and knee function, with curcumin offering additional benefits, such as a reduction in flatulence and weight loss. The