This 2024 observational study published in Nature Communications (DOI: 10.1038/s41467-024-50098-2) introduces the PRC2-AgeIndex, a novel biomarker of aging based on DNA methylation patterns at low-methylated regions (LMRs) bound by Polycomb Repressive Complex 2 (PRC2). Researchers found that these regions gain methylation consistently across various somatic tissues with age, accounting for
