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Tag: anti-aging interventions

PRC2-AgeIndex as a universal biomarker of aging and rejuvenation

This 2024 observational study published in Nature Communications (DOI: 10.1038/s41467-024-50098-2) introduces the PRC2-AgeIndex, a novel biomarker of aging based on DNA methylation patterns at low-methylated regions (LMRs) bound by Polycomb Repressive Complex 2 (PRC2). Researchers found that these regions gain methylation consistently across various somatic tissues with age, accounting for

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June 26, 2025 No Comments

Aging Biomarkers and Novel Targets for Anti-Aging Interventions

This 2018 review article published in Advances in Experimental Medicine and Biology (DOI: 10.1007/978-3-030-25650-0_3, PMID: 31493221) explores various aging biomarkers, such as telomeres, longevity proteins, senescence-associated secretory phenotypes, and gut microbiota, while assessing their potential as therapeutic targets for anti-aging interventions. The review highlights how these biomarkers are linked to

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June 26, 2025 No Comments