This 2017 review explores the role of oxidative stress and inflammation in telomere shortening, a key factor in cellular aging. It presents evidence that antioxidants (e.g., vitamins C and E, polyphenols) and anti-inflammatory agents (e.g., omega-3 fatty acids, statins) can mitigate telomere attrition by reducing oxidative damage and inflammatory responses.
This 2022 observational study used data from 4,039 U.S. adults aged 45 and older (NHANES 1999–2002) to explore the relationship between dietary magnesium intake and leukocyte telomere length (LTL), a biomarker of cellular aging. Researchers found that higher magnesium intake was significantly associated with longer LTL, with participants consuming ≥299
This 2024 observational study published in Nature Communications (DOI: 10.1038/s41467-024-50098-2) introduces the PRC2-AgeIndex, a novel biomarker of aging based on DNA methylation patterns at low-methylated regions (LMRs) bound by Polycomb Repressive Complex 2 (PRC2). Researchers found that these regions gain methylation consistently across various somatic tissues with age, accounting for
The review article titled “Dehydroepiandrosterone, Cancer, and Aging” (Aging and Disease, 2022, PMID: 35430962) evaluates the potential benefits of dehydroepiandrosterone (DHEA), the most abundant circulating steroid hormone, in preventing and managing age-related diseases, particularly cancer and metabolic disorders. It highlights DHEA’s proposed mechanism of action, including inhibition of glucose-6-phosphate dehydrogenase
