This 2015 review by Josh Mitteldorf explores the concept of programmed aging, suggesting that aging may be an active, genetically regulated process rather than solely the result of wear and tear. The author argues that if aging is programmatically controlled, it could be more amenable to therapeutic interventions aimed at
This 2024 observational study published in Nature Communications (DOI: 10.1038/s41467-024-50098-2) introduces the PRC2-AgeIndex, a novel biomarker of aging based on DNA methylation patterns at low-methylated regions (LMRs) bound by Polycomb Repressive Complex 2 (PRC2). Researchers found that these regions gain methylation consistently across various somatic tissues with age, accounting for
This 2025 systematic review published in Geriatrics and Gerontology International (DOI: 10.1111/ggi.15054) explores the latest advances in biomarkers for cellular senescence, emphasizing their potential role in diagnosing and treating age-related diseases. The review discusses various biomarkers such as senescence-associated β-galactosidase, DNA-damage-related markers, and the senescence-associated secretory phenotype (SASP). It highlights
