This narrative review examines the role of amino acids (AAs) in parenteral nutrition (PN), emphasizing their critical function in preserving or enhancing muscle mass, particularly in patients unable to meet nutritional needs enterally. It discusses the availability of various industrial PN mixtures and the potential for personalized compounded mixtures tailored
This 2020 review examines how dietary carbohydrates and lipids influence intestinal permeability associated with leaky gut syndrome (LGS). High fructose intake is linked to tight junction dysfunction and increased permeability, potentially leading to dysbiosis. Short-chain fatty acids like butyrate may enhance barrier integrity, while the effects of long-chain fatty acids,
This 2020 review explores the influence of nutrition on the development and management of Hashimoto’s thyroiditis (HT), an autoimmune thyroid disease. It underscores the interplay between genetic susceptibility and environmental triggers, particularly dietary factors. The article details how deficiencies in selenium, iodine, iron, zinc, magnesium, copper, and vitamins A, B,
This review discusses the potential benefits of methionine restriction as a therapeutic approach in cancer treatment. It explains how reducing methionine intake inhibits cancer cell growth by limiting methylation, polyamine synthesis, and glutathione formation, all critical processes for tumor growth. Methionine restriction may enhance the efficacy of chemotherapy and offers
This cohort study investigated the relationship between dietary intake and homocysteine levels in individuals with the MTHFR C677T polymorphism in a Chinese population. The study found that increased consumption of fish and eggs was associated with lower homocysteine levels, particularly for those with the CT genotype. These results suggest that
This study analyzed the relationship between the MTHFR gene polymorphism (C677T) and cardiovascular risks in a Chinese population with low folate intake. It found that individuals with the TT genotype had a significantly higher risk of stroke and heart disease compared to those with the CC genotype. The findings suggest
This study examined the effect of genetic polymorphisms in enzymes involved in homocysteine metabolism (MTHFR, CBS, and MS) on plasma homocysteine responses to dietary folate in healthy women. Participants (n=37) underwent a crossover dietary intervention with low and high folate diets. Results showed that high folate intake significantly increased serum
This study analyzed the impact of the MTHFR C677T polymorphism on folate metabolism and its effects on health. Using liquid chromatography-tandem mass spectrometry (LC-MS/MS), the study identified changes in folate-related metabolites in individuals with this genetic variant, particularly in 5-methyltetrahydrofolate levels and metabolites involved in DNA synthesis. The findings highlight
This study investigated the effect of folic acid (B9) and vitamin B12 supplementation on lowering plasma total homocysteine (tHcy) levels in hemodialysis (HD) patients, specifically focusing on the impact of MTHFR (C677T) genotypes. It involved 132 HD patients who were randomized to receive B9, B12, or a combination of both
This review article explores how genetic variations affect choline metabolism and dietary requirements. It highlights that men and postmenopausal women are more likely to experience liver or muscle dysfunction when deprived of dietary choline, while premenopausal women may resist choline deficiency due to estrogen-induced expression of the PEMT gene, which
